eprintid: 10206649 rev_number: 6 eprint_status: archive userid: 699 dir: disk0/10/20/66/49 datestamp: 2025-03-28 12:19:42 lastmod: 2025-03-28 12:19:42 status_changed: 2025-03-28 12:19:42 type: article metadata_visibility: show sword_depositor: 699 creators_name: Locks, A creators_name: Bowles, BJ creators_name: Brown, S creators_name: Hailes, HC creators_name: Hilton, ST title: 3D Printing with tuneable degradation: Thiol-ene and thiol-yne containing formulations for biomedical applications ispublished: pub divisions: UCL divisions: B02 divisions: B04 divisions: C08 divisions: C06 divisions: D10 divisions: F56 divisions: G09 keywords: 3D Printing, Biodegradable Materials, Biomedical Applications, Digital Light Processing (DLP), Drug Delivery Systems, Programmable Degradation, Thiol-Ene Polymers note: © 2025 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). abstract: Despite advances in the range of materials that can be used in 3D printing and their applications across numerous scientific disciplines, the controlled breakdown of their solid structures after printing remains challenging. In this study we report the development of tuneable degradable 3D printed formulations, that could be 3D printed using standard digital light processing (DLP) and then degraded as required under mild conditions. Thirteen thiol-ene and thiol-yne formulations were designed to provide a range of tailored mechanical properties, with controlled degradation rates, and specific thermal behaviours with potential relevance to biomedical applications. The formulations ranged from ones with high stiffness for structural applications, through to those capable of rapid degradation. These formulations demonstrate full degradability and stability in physiological conditions, showing potential for future drug delivery applications pending further toxicity and release studies. This balance of degradability and mechanical robustness offers significant potential for enhancing patient safety and reducing the invasiveness of surgical treatments as directed by clinical needs. date: 2025-04-15 date_type: published publisher: Elsevier BV official_url: https://doi.org/10.1016/j.ijpharm.2025.125432 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2370493 doi: 10.1016/j.ijpharm.2025.125432 medium: Print-Electronic pii: S0378-5173(25)00268-6 lyricists_name: Hilton, Stephen lyricists_name: Hailes, Helen lyricists_id: SHILT85 lyricists_id: HCHAI24 actors_name: Hailes, Helen actors_id: HCHAI24 actors_role: owner funding_acknowledgements: [Engineering and Physical Sciences Research Council] full_text_status: public publication: International Journal of Pharmaceutics volume: 674 article_number: 125432 event_location: Netherlands issn: 0378-5173 citation: Locks, A; Bowles, BJ; Brown, S; Hailes, HC; Hilton, ST; (2025) 3D Printing with tuneable degradation: Thiol-ene and thiol-yne containing formulations for biomedical applications. International Journal of Pharmaceutics , 674 , Article 125432. 10.1016/j.ijpharm.2025.125432 <https://doi.org/10.1016/j.ijpharm.2025.125432>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10206649/1/Amy%20Locks%20et%20al.pdf