<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10206585> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/title> "Gene Therapy-Associated Uveitis (GTAU): Understanding and mitigating the adverse immune response in retinal gene therapy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/abstract> "Retinal gene therapy using adeno-associated viral (AAV) vectors has been a groundbreaking step-change in the treatment of inherited retinal diseases (IRDs) and could also be used to treat more common retinal diseases such as age-related macular degeneration and diabetic retinopathy. The delivery and expression of therapeutic transgenes in the eye is limited by innate and adaptive immune responses against components of the vector product, which has been termed gene therapy-associated uveitis (GTAU). This is clinically important as intraocular inflammation could lead to irreversible loss of retinal cells, deterioration of visual function and reduced durability of treatment effect associated with a costly one-off treatment. For retinal gene therapy to achieve an improved efficacy and safety profile for treating additional IRDs and more common diseases, the risk of GTAU must be minimised. We have collated insights from pre-clinical research, clinical trials, and the real-world implementation of AAV-mediated retinal gene therapy to help understand the risk factors for GTAU. We draw attention to an emerging framework, which includes patient demographics, vector construct, vector dose, route of administration, and choice of immunosuppression regime. Importantly, we consider efforts to date and potential future strategies to mitigate the adverse immune response across each of these domains. We advocate for more targeted immunomodulatory approaches to the prevention and treatment of GTAU based on better understanding of the underlying immune response."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/date> "2025-05" .
<https://discovery.ucl.ac.uk/id/document/1843145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> .
<https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> <http://xmlns.com/foaf/0.1/name> "Elsevier BV"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/publisher> <https://discovery.ucl.ac.uk/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1> .
<https://discovery.ucl.ac.uk/id/publication/ext-96b9c2f2f63011532ba4107270fab3ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-96b9c2f2f63011532ba4107270fab3ca> <http://xmlns.com/foaf/0.1/name> "Prog Retin Eye Res"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-96b9c2f2f63011532ba4107270fab3ca> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-258f5f13a73a4f108d10d90602522411> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-258f5f13a73a4f108d10d90602522411> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-49e147428d039c93f4c325a6d921a993> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-49e147428d039c93f4c325a6d921a993> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-229a8026d1ec9c53d88fb2b8adb4e606> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-229a8026d1ec9c53d88fb2b8adb4e606> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ba060069de40a27280de78f47ed9c617> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-ba060069de40a27280de78f47ed9c617> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9fe929d3fbd65ba0a3e5b26af9d2c803> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-9fe929d3fbd65ba0a3e5b26af9d2c803> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> .
<https://discovery.ucl.ac.uk/id/eprint/10206585> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10206585#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10206585#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> .
<https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> <http://xmlns.com/foaf/0.1/givenName> "M Dominik"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> <http://xmlns.com/foaf/0.1/familyName> "Fischer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ce8c7c6f2b425e484ac4b9536ae95c5f> <http://xmlns.com/foaf/0.1/name> "M Dominik Fischer"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> <http://xmlns.com/foaf/0.1/givenName> "Andrew D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> <http://xmlns.com/foaf/0.1/familyName> "Dick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6e044183b5088a6e6498b881817920c6> <http://xmlns.com/foaf/0.1/name> "Andrew D Dick"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> <http://xmlns.com/foaf/0.1/givenName> "Kanmin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> <http://xmlns.com/foaf/0.1/familyName> "Xue"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5b5f02c1888c94453893c072f9b73ebf> <http://xmlns.com/foaf/0.1/name> "Kanmin Xue"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> <http://xmlns.com/foaf/0.1/givenName> "Molly"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> <http://xmlns.com/foaf/0.1/familyName> "John"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-df0edb236ac4b4ea1b5158d09b2532bd> <http://xmlns.com/foaf/0.1/name> "Molly John"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> <http://xmlns.com/foaf/0.1/givenName> "Ryan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> <http://xmlns.com/foaf/0.1/familyName> "Purdy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f58148509e44adbec585e5ddbecd3999> <http://xmlns.com/foaf/0.1/name> "Ryan Purdy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> <http://xmlns.com/foaf/0.1/givenName> "David A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> <http://xmlns.com/foaf/0.1/familyName> "Copland"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c9876f59bf289196aaac78f116377fea> <http://xmlns.com/foaf/0.1/name> "David A Copland"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> <http://xmlns.com/foaf/0.1/givenName> "Fanny"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> <http://xmlns.com/foaf/0.1/familyName> "Nerinckx"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a8f4632540866733cd83795db68eb2d6> <http://xmlns.com/foaf/0.1/name> "Fanny Nerinckx"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> <http://xmlns.com/foaf/0.1/givenName> "Mark E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> <http://xmlns.com/foaf/0.1/familyName> "Pennesi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f4124d79b72f449176beb1d3705559ac> <http://xmlns.com/foaf/0.1/name> "Mark E Pennesi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> <http://xmlns.com/foaf/0.1/givenName> "Alissa"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> <http://xmlns.com/foaf/0.1/familyName> "Bray"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-257d54955c3baaeb606d16315f863a92> <http://xmlns.com/foaf/0.1/name> "Alissa Bray"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> <http://xmlns.com/foaf/0.1/givenName> "Robert H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> <http://xmlns.com/foaf/0.1/familyName> "Henderson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4bf147298912b5ed59a3d8412fddaae7> <http://xmlns.com/foaf/0.1/name> "Robert H Henderson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49e147428d039c93f4c325a6d921a993> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-49e147428d039c93f4c325a6d921a993> <http://xmlns.com/foaf/0.1/givenName> "Ying Kai"^^<http://www.w3.org/2001/XMLSchema#string> .
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