eprintid: 10206227
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/20/62/27
datestamp: 2025-03-17 14:48:53
lastmod: 2025-03-17 14:48:53
status_changed: 2025-03-17 14:48:53
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Lu, Wei-Ting
creators_name: Kanu, Nnennaya
title: FAT1 alterations contribute to chromosomal instability in cancer cells
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D19
divisions: G99
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.
date: 2025-01
date_type: published
publisher: NATURE PORTFOLIO
official_url: https://doi.org/10.1038/s41556-024-01559-9
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2354997
doi: 10.1038/s41556-024-01559-9
lyricists_name: Kanu, Nnennaya
lyricists_id: NKANU55
actors_name: Kanu, Nnennaya
actors_name: Kalinowski, Damian
actors_id: NKANU55
actors_id: DKALI47
actors_role: owner
actors_role: impersonator
full_text_status: restricted
publication: Nature Cell Biology
volume: 27
number: 1
pagerange: 12-13
pages: 2
citation:        Lu, Wei-Ting;    Kanu, Nnennaya;      (2025)    FAT1 alterations contribute to chromosomal instability in cancer cells.                   Nature Cell Biology , 27  (1)   pp. 12-13.    10.1038/s41556-024-01559-9 <https://doi.org/10.1038/s41556-024-01559-9>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10206227/1/Kanu_FAT1%20alterations%20contribute%20to%20chromosomal%20instability%20in%20cancer%20cells_AAM.pdf