%N 1 %I NATURE PORTFOLIO %L discovery10206227 %X Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling. %J Nature Cell Biology %A Wei-Ting Lu %A Nnennaya Kanu %T FAT1 alterations contribute to chromosomal instability in cancer cells %P 12-13 %D 2025 %O This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. %V 27