TY  - JOUR
VL  - 36
SP  - 250
N1  - This version is the author-accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
IS  - 3
SN  - 0956-4624
UR  - https://doi.org/10.1177/09564624241298983
A1  - Ismail, Muhammad Azam
A1  - Tittle, Victoria
A1  - Jones, Rachael
A1  - Loftus, Hannah
A1  - Girometti, Nicolo
A1  - Dosekun, Olamide
A1  - Stegmann, Katrina
A1  - Pool, Erica
A1  - Tariq, Shema
A1  - Nakamura, Anna
A1  - Tyler, Stephanie
A1  - Coleman, Harry
A1  - Teh, Yee Suh
A1  - Boffito, Marta
JF  - International Journal of STD and AIDS
EP  - 254
AV  - public
Y1  - 2025/03//
TI  - Therapeutic drug monitoring of tenofovir disoproxil and emtricitabine in oral HIV pre-exposure prophylaxis (PrEP) users who have undergone gastrointestinal surgery
PB  - Royal Society of Medicine Press
ID  - discovery10206201
N2  - Objectives:
Oral HIV pre-exposure prophylaxis (PrEP) is highly effective in preventing HIV, but its efficacy depends on adequate absorption of drug, which may decrease following gastrointestinal surgery.//
Methods:
Clinicians across eight Genito-urinary Medicine clinics in the United Kingdom submitted data on PrEP users with history of gastrointestinal surgery who were referred to a national complex PrEP multi-disciplinary team between June 2021 and April 2023. Anonymised data were submitted on demographics, surgical history, PrEP regimen, and results of therapeutic drug monitoring (TDM) and HIV screening tests. Descriptive analyses were performed in SPSS version 29.//
Results:
Nine cases described cis-gender men-who-have-sex-with-men (MSM) with median age of 47.4 years (IQR = 43 ? 56.5) taking tenofovir disoproxil (TDF)/emtricitabine (FTC) daily (n = 8) or event-based (n = 1) as PrEP. Median time between PrEP initiation and TDM was 53 days (IQR = 8.5?1705). The mean (ąSD) trough concentration of tenofovir (TFV) and FTC were 90.2 ą 27.7 ng/mL and 76.0 ą 45.9 ng/mL, respectively. All patients had a negative HIV test at follow-up.//
Conclusions:
Plasma trough concentrations of TFV observed in our cohort taking TDF/FTC were above the expected concentrations associated with PrEP efficacy as previously described in the literature, suggesting that PrEP can be safely given in this population, with TDM used for reassurance.
KW  - Pre-exposure prophylaxis
KW  -  therapeutic drug monitoring
KW  -  HIV
KW  -  gastrointestinal surgery
ER  -