eprintid: 10206140 rev_number: 9 eprint_status: archive userid: 699 dir: disk0/10/20/61/40 datestamp: 2025-03-18 11:43:15 lastmod: 2025-03-18 11:43:15 status_changed: 2025-03-18 11:43:15 type: article metadata_visibility: show sword_depositor: 699 creators_name: Briggs, Juliet creators_name: Ralston, Elizabeth creators_name: Wilkinson, Thomas J creators_name: Walklin, Christy creators_name: Mangahis, Emmanuel creators_name: Young, Hannah ML creators_name: Castle, Ellen M creators_name: Billany, Roseanne E creators_name: Asgari, Elham creators_name: Bhandari, Sunil creators_name: Bramham, Kate creators_name: Burton, James O creators_name: Campbell, Jackie creators_name: Chilcot, Joseph creators_name: Deelchand, Vashist creators_name: Hamilton, Alexander creators_name: Jesky, Mark creators_name: Kalra, Philip A creators_name: McCafferty, Kieran creators_name: Nixon, Andrew C creators_name: Saynor, Zoe L creators_name: Taal, Maarten W creators_name: Tollitt, James creators_name: Wheeler, David C creators_name: Macdonald, Jamie creators_name: Greenwood, Sharlene A title: Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G93 keywords: Digital health intervention, exercise, physical activity, polycystic kidney disease, quality of life note: This work is licensed under a Creative Commons License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ abstract: BACKGROUND: In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. METHODS: This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. RESULTS: All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0-7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales-burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)-were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. CONCLUSION: A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour. date: 2025-03 date_type: published publisher: Oxford University Press (OUP) official_url: https://doi.org/10.1093/ckj/sfaf041 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2370484 doi: 10.1093/ckj/sfaf041 pii: sfaf041 lyricists_name: Wheeler, David lyricists_id: DWHEE12 actors_name: Wheeler, David actors_id: DWHEE12 actors_role: owner full_text_status: public publication: Clinical Kidney Journal volume: 18 number: 3 article_number: sfaf041 event_location: England citation: Briggs, Juliet; Ralston, Elizabeth; Wilkinson, Thomas J; Walklin, Christy; Mangahis, Emmanuel; Young, Hannah ML; Castle, Ellen M; ... Greenwood, Sharlene A; + view all <#> Briggs, Juliet; Ralston, Elizabeth; Wilkinson, Thomas J; Walklin, Christy; Mangahis, Emmanuel; Young, Hannah ML; Castle, Ellen M; Billany, Roseanne E; Asgari, Elham; Bhandari, Sunil; Bramham, Kate; Burton, James O; Campbell, Jackie; Chilcot, Joseph; Deelchand, Vashist; Hamilton, Alexander; Jesky, Mark; Kalra, Philip A; McCafferty, Kieran; Nixon, Andrew C; Saynor, Zoe L; Taal, Maarten W; Tollitt, James; Wheeler, David C; Macdonald, Jamie; Greenwood, Sharlene A; - view fewer <#> (2025) Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial. Clinical Kidney Journal , 18 (3) , Article sfaf041. 10.1093/ckj/sfaf041 <https://doi.org/10.1093/ckj%2Fsfaf041>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10206140/1/Wheeler_sfaf041.pdf