TY  - JOUR
AV  - public
Y1  - 2025/03//
VL  - 18
TI  - Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial
N1  - This work is licensed under a Creative Commons License. The images
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unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
IS  - 3
PB  - Oxford University Press (OUP)
UR  - https://doi.org/10.1093/ckj/sfaf041
ID  - discovery10206140
N2  - BACKGROUND: In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD. METHODS: This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews. RESULTS: All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0-7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales-burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)-were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management. CONCLUSION: A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.
KW  - Digital health intervention
KW  -  exercise
KW  -  physical activity
KW  -  polycystic kidney disease
KW  -  quality of life
A1  - Briggs, Juliet
A1  - Ralston, Elizabeth
A1  - Wilkinson, Thomas J
A1  - Walklin, Christy
A1  - Mangahis, Emmanuel
A1  - Young, Hannah ML
A1  - Castle, Ellen M
A1  - Billany, Roseanne E
A1  - Asgari, Elham
A1  - Bhandari, Sunil
A1  - Bramham, Kate
A1  - Burton, James O
A1  - Campbell, Jackie
A1  - Chilcot, Joseph
A1  - Deelchand, Vashist
A1  - Hamilton, Alexander
A1  - Jesky, Mark
A1  - Kalra, Philip A
A1  - McCafferty, Kieran
A1  - Nixon, Andrew C
A1  - Saynor, Zoe L
A1  - Taal, Maarten W
A1  - Tollitt, James
A1  - Wheeler, David C
A1  - Macdonald, Jamie
A1  - Greenwood, Sharlene A
JF  - Clinical Kidney Journal
ER  -