eprintid: 10206115 rev_number: 9 eprint_status: archive userid: 699 dir: disk0/10/20/61/15 datestamp: 2025-03-14 10:52:48 lastmod: 2025-03-14 10:52:48 status_changed: 2025-03-14 10:52:48 type: article metadata_visibility: show sword_depositor: 699 creators_name: Howell, KB creators_name: White, SM creators_name: McTague, A creators_name: D’Gama, AM creators_name: Costain, G creators_name: Poduri, A creators_name: Scheffer, IE creators_name: Chau, V creators_name: Smith, LD creators_name: Stephenson, SEM creators_name: Wojcik, M creators_name: Davidson, A creators_name: Sebire, N creators_name: Sliz, P creators_name: Beggs, AH creators_name: Chitty, LS creators_name: Cohn, RD creators_name: Marshall, CR creators_name: Andrews, NC creators_name: North, KN creators_name: Cross, JH creators_name: Christodoulou, J creators_name: Scherer, SW title: International Precision Child Health Partnership (IPCHiP): an initiative to accelerate discovery and improve outcomes in rare pediatric disease ispublished: pub divisions: UCL divisions: B02 divisions: D13 divisions: G28 divisions: G26 divisions: G23 divisions: G25 note: This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. abstract: Advances in genomic technologies have revolutionized the diagnosis of rare genetic diseases, leading to the emergence of precision therapies. However, there remains significant effort ahead to ensure the promise of precision medicine translates to improved outcomes. Here, we discuss the challenges in advancing precision child health and highlight how international collaborations such as the International Precision Child Health Partnership, which embed research into clinical care, can maximize benefits for children globally. date: 2025-02-27 date_type: published publisher: Springer Science and Business Media LLC official_url: https://doi.org/10.1038/s41525-025-00474-8 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2365795 doi: 10.1038/s41525-025-00474-8 medium: Electronic pii: 10.1038/s41525-025-00474-8 lyricists_name: Chitty, Lyn lyricists_name: Sebire, Neil lyricists_name: Cross, Judith lyricists_name: McTague, Amy lyricists_id: LCHIT39 lyricists_id: NJSEB45 lyricists_id: JHCRO62 lyricists_id: AMCTA71 actors_name: McTague, Amy actors_id: AMCTA71 actors_role: owner funding_acknowledgements: P50 HD105351 [NICHD NIH HHS]; T32 HD098061 [NICHD NIH HHS] full_text_status: public publication: npj Genomic Medicine volume: 10 article_number: 13 event_location: England issn: 2056-7944 citation: Howell, KB; White, SM; McTague, A; D’Gama, AM; Costain, G; Poduri, A; Scheffer, IE; ... Scherer, SW; + view all <#> Howell, KB; White, SM; McTague, A; D’Gama, AM; Costain, G; Poduri, A; Scheffer, IE; Chau, V; Smith, LD; Stephenson, SEM; Wojcik, M; Davidson, A; Sebire, N; Sliz, P; Beggs, AH; Chitty, LS; Cohn, RD; Marshall, CR; Andrews, NC; North, KN; Cross, JH; Christodoulou, J; Scherer, SW; - view fewer <#> (2025) International Precision Child Health Partnership (IPCHiP): an initiative to accelerate discovery and improve outcomes in rare pediatric disease. npj Genomic Medicine , 10 , Article 13. 10.1038/s41525-025-00474-8 <https://doi.org/10.1038/s41525-025-00474-8>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10206115/1/McTague_s41525-025-00474-8.pdf