eprintid: 10206100
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/20/61/00
datestamp: 2025-03-14 09:14:26
lastmod: 2025-03-14 09:14:26
status_changed: 2025-03-14 09:14:26
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Leung, Sharon SY
creators_name: Tsang, Helen SL
creators_name: Chan, Jasmine
creators_name: Kui, Oliver YH
creators_name: Zeng, Ping
creators_name: Cheung, Yin Ting
creators_name: Cheng, James-Wesley
creators_name: Chan, Kate CC
creators_name: Yu, Michelle
creators_name: Tang, Patricia
creators_name: Brannan, John D
creators_name: Lam, Jenny KW
creators_name: Chan, Hak-Kim
creators_name: Li, Albert M
title: Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – Impacts of body mass index
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Paediatric asthma; asthma control; mannitol challenge test; bronchial hyperresponsiveness; body mass index
note: © 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
abstract: Background:
Increasing epidemiological studies reported that overweight/obese asthma patients had more frequent and severe symptoms and exacerbations, indicating their asthma management may not be sufficient. Airway hyperresponsiveness (AHR), a significant feature of asthma, was found to link with the body mass index (BMI) with mixed findings using the “direct” methacholine challenge test. The objective was to examine the association between BMI and asthma control, as reflected by the “indirect” AHR with the mannitol challenge test in a paediatric asthmatic population.

Methods:
A total of 80 subjects with physician-diagnosed asthma, aged 6–18 years were enrolled in this cross-sectional study. Patients were first asked to complete the Asthma Control Test (ACT) questionnaire to self-evaluate their disease status. A mannitol challenge test was then performed to assess their AHR severity.

Results:
Seventy-six patients (96%) rated their asthma as well-controlled with an ACT score ≥ 20, but 42 patients (53%) were tested positive in the mannitol challenge test with mild and moderate AHR. While patients with mild AHR had comparable lung functions to those without AHR, patients with moderate AHR showed slightly but significantly lower FEV1 and FEV1/FVC values. Although no significant difference in the BMI values was noted for patients with different levels of AHR, the trend of increasing BMI with age was steeper for patients with moderate AHR.

Conclusion:
A high prevalence of AHR (>50%) was found in asthmatic children who self-evaluated with good asthma control. No significant influence of the BMI on the AHR severity could be demonstrated in this population with the “indirect” mannitol challenge test. Since only a small number of overweight/obese subjects were recruited in the present study, further verification of the results with a larger sample size of obese subjects is required.
date: 2025-02-20
date_type: published
publisher: TAYLOR & FRANCIS LTD
official_url: https://doi.org/10.1080/07853890.2025.2468262
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2366673
doi: 10.1080/07853890.2025.2468262
lyricists_name: Lam, Ka Wing
lyricists_id: KWLAM29
actors_name: Harris, Jean
actors_id: JAHAR68
actors_role: owner
funding_acknowledgements: 04180037 [Health and Medical Research Fund, Research Fellowship Scheme, Food and Health Bureau, Hong Kong SAR Government]
full_text_status: public
publication: Annals of Medicine
volume: 57
number: 1
article_number: 2468262
pages: 10
issn: 0785-3890
citation:        Leung, Sharon SY;    Tsang, Helen SL;    Chan, Jasmine;    Kui, Oliver YH;    Zeng, Ping;    Cheung, Yin Ting;    Cheng, James-Wesley;                             ... Li, Albert M; + view all <#>        Leung, Sharon SY;  Tsang, Helen SL;  Chan, Jasmine;  Kui, Oliver YH;  Zeng, Ping;  Cheung, Yin Ting;  Cheng, James-Wesley;  Chan, Kate CC;  Yu, Michelle;  Tang, Patricia;  Brannan, John D;  Lam, Jenny KW;  Chan, Hak-Kim;  Li, Albert M;   - view fewer <#>    (2025)    Evaluation of bronchial hyperresponsiveness in asthmatic paediatric patients using mannitol challenge test – Impacts of body mass index.                   Annals of Medicine , 57  (1)    , Article 2468262.  10.1080/07853890.2025.2468262 <https://doi.org/10.1080/07853890.2025.2468262>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10206100/1/Evaluation%20of%20bronchial%20hyperresponsiveness.pdf