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<https://discovery.ucl.ac.uk/id/eprint/10205884> <http://purl.org/dc/terms/title> "Exploring the effect of COVID-19 restrictions on the Social Functioning Scale in a clinical trial of Antipsychotic Reduction: using multiple imputation to target a hypothetical estimand"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10205884> <http://purl.org/ontology/bibo/abstract> "Objective:\r\nMany trials are affected by unforeseen events after recruitment has commenced. The aim of this study is to explore a hypothetical strategy for dealing with an intercurrent event that occurred during trial follow-up; COVID-19 restrictions.//\r\n\r\nStudy Design and Setting:\r\nSecondary analysis of a randomised controlled trial in schizophrenia, comparing antipsychotic reduction versus maintenance medication on the Social Functioning Scale (SFS) score at 12 months’ follow-up. A hypothetical analysis strategy was used to estimate the treatment effect in a COVID-19 restriction-free world. Outcome data were set to missing and multiple imputation was used to replace values affected by COVID-19.//\r\nResults:\r\nThe trial randomised 253 participants, 187 participants had an SFS score at 12 months, 75 of those were collected during COVID-19 restrictions. In the original complete case regression analysis, targeting a treatment policy estimand, the treatment effect was estimated to be 0.51 (95%CI -1.33, 2.35) points higher in the reduction group. After multiple imputation, targeting the hypothetical estimand, the mean SFS score was -3.01 (95%CI -7.22, 1.20) points lower in the reduction group, but varied with different assumptions about the timing of events and in sensitivity analyses to increase the size of difference between randomised groups.//\r\nConclusion:\r\nWe demonstrated how the intervention effect can change when estimating the intervention effect in a pandemic world (treatment policy estimand) versus a pandemic restriction-free world (hypothetical estimand) and that estimates are sensitive to imputation and input assumptions. Trialists should be aware of potential intercurrent events and plan the analysis to take them into account."^^<http://www.w3.org/2001/XMLSchema#string> .
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