eprintid: 10205883
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/58/83
datestamp: 2025-03-11 10:47:49
lastmod: 2025-03-11 10:47:49
status_changed: 2025-03-11 10:47:49
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Zhu, Zhuoting
creators_name: Wang, Yueye
creators_name: Qi, Ziyi
creators_name: Hu, Wenyi
creators_name: Zhang, Xiayin
creators_name: Wagner, Siegfried K
creators_name: Wang, Yujie
creators_name: Ran, An Ran
creators_name: Ong, Joshua
creators_name: Waisberg, Ethan
creators_name: Masalkhi, Mouayad
creators_name: Suh, Alex
creators_name: Tham, Yih Chung
creators_name: Cheung, Carol Y
creators_name: Yang, Xiaohong
creators_name: Yu, Honghua
creators_name: Ge, Zongyuan
creators_name: Wang, Wei
creators_name: Sheng, Bin
creators_name: Liu, Yun
creators_name: Lee, Andrew G
creators_name: Denniston, Alastair K
creators_name: Wijngaarden, Peter van
creators_name: Keane, Pearse A
creators_name: Cheng, Ching-Yu
creators_name: He, Mingguang
creators_name: Wong, Tien Yin
title: Oculomics: Current Concepts and Evidence
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D08
keywords: Artificial intelligence, Big data, Disease detection, Disease prediction, Oculomics, Retinal imaging, Systemic diseases
note: © The Author(s), 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/
abstract: The eye provides novel insights into general health, as well as pathogenesis and development of systemic diseases. In the past decade, growing evidence has demonstrated that the eye's structure and function mirror multiple systemic health conditions, especially in cardiovascular diseases, neurodegenerative disorders, and kidney impairments. This has given rise to the field of oculomics- the application of ophthalmic biomarkers to understand mechanisms, detect and predict disease. The development of this field has been accelerated by three major advances: 1) the availability and widespread clinical adoption of high-resolution and non-invasive ophthalmic imaging (“hardware”); 2) the availability of large studies to interrogate associations (“big data”); 3) the development of novel analytical methods, including artificial intelligence (AI) (“software”). Oculomics offers an opportunity to enhance our understanding of the interplay between the eye and the body, while supporting development of innovative diagnostic, prognostic, and therapeutic tools. These advances have been further accelerated by developments in AI, coupled with large-scale linkage datasets linking ocular imaging data with systemic health data. Oculomics also enables the detection, screening, diagnosis, and monitoring of many systemic health conditions. Furthermore, oculomics with AI allows prediction of the risk of systemic diseases, enabling risk stratification, opening up new avenues for prevention or individualized risk prediction and prevention, facilitating personalized medicine. In this review, we summarise current concepts and evidence in the field of oculomics, highlighting the progress that has been made, remaining challenges, and the opportunities for future research.
date: 2025-03-04
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.preteyeres.2025.101350
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2367457
doi: 10.1016/j.preteyeres.2025.101350
medium: Print-Electronic
pii: S1350-9462(25)00023-0
lyricists_name: Keane, Pearse
lyricists_id: KPEAR28
actors_name: Keane, Pearse
actors_id: KPEAR28
actors_role: owner
full_text_status: public
publication: Progress in Retinal and Eye Research
article_number: 101350
event_location: England
issn: 1350-9462
citation:        Zhu, Zhuoting;    Wang, Yueye;    Qi, Ziyi;    Hu, Wenyi;    Zhang, Xiayin;    Wagner, Siegfried K;    Wang, Yujie;                                                                                 ... Wong, Tien Yin; + view all <#>        Zhu, Zhuoting;  Wang, Yueye;  Qi, Ziyi;  Hu, Wenyi;  Zhang, Xiayin;  Wagner, Siegfried K;  Wang, Yujie;  Ran, An Ran;  Ong, Joshua;  Waisberg, Ethan;  Masalkhi, Mouayad;  Suh, Alex;  Tham, Yih Chung;  Cheung, Carol Y;  Yang, Xiaohong;  Yu, Honghua;  Ge, Zongyuan;  Wang, Wei;  Sheng, Bin;  Liu, Yun;  Lee, Andrew G;  Denniston, Alastair K;  Wijngaarden, Peter van;  Keane, Pearse A;  Cheng, Ching-Yu;  He, Mingguang;  Wong, Tien Yin;   - view fewer <#>    (2025)    Oculomics: Current Concepts and Evidence.                   Progress in Retinal and Eye Research      , Article 101350.  10.1016/j.preteyeres.2025.101350 <https://doi.org/10.1016/j.preteyeres.2025.101350>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205883/1/Keane_Oculomics_Current%20Concepts%20and%20Evidence._1-s2.0-S1350946225000230-main.pdf