<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10205784> .
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<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/title> "Commentary: Tolvaptan for Autosomal Dominant Polycystic Kidney Disease (ADPKD) - an update"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/abstract> "Autosomal Dominant Polycystic Kidney Disease (ADPKD) affects up to 70 000 people in the UK and the most common inherited cause of end-stage kidney disease (ESKD). It is generally a late-onset multisystem disorder characterised by bilateral kidney cysts, liver cysts and an increased risk of intracranial aneurysms. Approximately 50% of people with ADPKD reach ESKD by age 60. Disease-associated pain, discomfort, fatigue, emotional distress and, impaired mobility can impact health-related quality of life. The approval of tolvaptan, a vasopressin V2 receptor antagonist, has greatly advanced the care for people with ADPKD, shifting the focus from general chronic kidney disease management to targeted therapeutic approaches. While guidance from NICE and SMC provides a foundational framework, this is not clear or comprehensive enough to offer practical guidance for healthcare professionals in real-world settings. This commentary expands on the previous United Kingdom Kidney Association (UKKA) commentary in 2016 with an updated evidence base, the incorporation of real-world data and expert opinion to provide practical guidance to healthcare professionals. Through co-development with people affected by ADPKD, it now incorporates valuable patient perspectives and offers practical recommendations for the UK kidney community seeking to harmonise the quality of care of all people with ADPKD."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/date> "2025-02-14" .
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<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/volume> "26" .
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<https://discovery.ucl.ac.uk/id/org/ext-dcea299cf48188065b5f59a4cae50003> <http://xmlns.com/foaf/0.1/name> "Springer Science and Business Media LLC"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-14712369> <http://xmlns.com/foaf/0.1/name> "BMC Nephrology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-14712369> .
<https://discovery.ucl.ac.uk/id/publication/ext-14712369> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:14712369> .
<https://discovery.ucl.ac.uk/id/publication/ext-14712369> <http://purl.org/ontology/bibo/issn> "14712369" .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e448b67deb2a564883cbebabaf249b81> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-e448b67deb2a564883cbebabaf249b81> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-804cc9d5564b6771de4b85693abebf63> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-804cc9d5564b6771de4b85693abebf63> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> .
<https://discovery.ucl.ac.uk/id/eprint/10205784> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10205784#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10205784#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> .
<https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> <http://xmlns.com/foaf/0.1/familyName> "Chan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b88e0448579d67a169f6a3a6524b0d4e> <http://xmlns.com/foaf/0.1/name> "M Chan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> <http://xmlns.com/foaf/0.1/familyName> "Harris"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4c965a4ffb168a7a7d81c165ed675db0> <http://xmlns.com/foaf/0.1/name> "T Harris"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> <http://xmlns.com/foaf/0.1/familyName> "Acquaye"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b6590eac8b0dc8a1d1314cdb0ef4efc5> <http://xmlns.com/foaf/0.1/name> "A Acquaye"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> <http://xmlns.com/foaf/0.1/familyName> "Haley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d4f4f71a021f8ca32ca9f0f1504e9825> <http://xmlns.com/foaf/0.1/name> "H Haley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> <http://xmlns.com/foaf/0.1/familyName> "Williams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-99788c1ce0267a95bbbccc0c2ba9c818> <http://xmlns.com/foaf/0.1/name> "T Williams"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> <http://xmlns.com/foaf/0.1/familyName> "Gale"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-573b324c7f57542379a296d9e322087d> <http://xmlns.com/foaf/0.1/name> "D Gale"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-999de725cf1ad7fc831e9340eaf26b22> <http://xmlns.com/foaf/0.1/name> "E Lee"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> <http://xmlns.com/foaf/0.1/familyName> "Gittus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6b54391c187293c839f63667716e40e1> <http://xmlns.com/foaf/0.1/name> "M Gittus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> <http://xmlns.com/foaf/0.1/familyName> "Wong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-32f724dc5369ab6c3049548e4a239a98> <http://xmlns.com/foaf/0.1/name> "A Wong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> <http://xmlns.com/foaf/0.1/familyName> "Borrows"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-98715111cd86a2b04893b1b4bc0a68d1> <http://xmlns.com/foaf/0.1/name> "S Borrows"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> <http://xmlns.com/foaf/0.1/givenName> "ACM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> <http://xmlns.com/foaf/0.1/familyName> "Ong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-86292fb21f623d63cf84889208f12639> <http://xmlns.com/foaf/0.1/name> "ACM Ong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e448b67deb2a564883cbebabaf249b81> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e448b67deb2a564883cbebabaf249b81> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
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