eprintid: 10205642
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/56/42
datestamp: 2025-03-05 14:25:14
lastmod: 2025-03-05 14:25:14
status_changed: 2025-03-05 14:25:14
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Dasgupta, Debayan
creators_name: Elliott, Cameron A
creators_name: O’Keeffe, Aidan G
creators_name: Rodionov, Roman
creators_name: Li, Kuo
creators_name: Vakharia, Vejay N
creators_name: Mirza, Farhan A
creators_name: Tahir, M Zubair
creators_name: Tisdall, Martin M
creators_name: Miserocchi, Anna
creators_name: McEvoy, Andrew W
creators_name: Ourselin, Sebastien
creators_name: Sparks, Rachel E
creators_name: Duncan, John S
title: Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning
ispublished: pub
divisions: UCL
divisions: B02
divisions: D12
divisions: G19
note: © 2025 Dasgupta, Elliott, O’Keeffe, Rodionov, Li, Vakharia, Mirza, Tahir, Tisdall, Miserocchi, McEvoy, Ourselin, Sparks and Duncan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
abstract: OBJECTIVE: This study aims to refine computer-assisted planning (CAP) of SEEG implantations by adding spatial constraints from prior SEEG trajectories (“Priors”) to improve safety and reduce manual adjustments, without increasing planning time. METHODS: Retrospective validation based on 159 previously implanted trajectories (11 cases) planned by the clinical standard CAP and CAP constrained with spatial priors (“CAP + Priors”). Constraints included 31 target and 51 entry zones, created from 98 consecutive patients (763 implanted SEEG trajectories). Each of the 159 previously implanted trajectories was planned by two fellows, once with CAP and once with CAP + Priors, in a randomized order. The time taken to generate the initial computer-generated plan (T1) and the user-edited final plan (T2) were recorded together with the proportions of electrodes that required subsequent adjustments. Clinical implantability was assessed via a blinded review of each trajectory by five independent epilepsy neurosurgeons with expertise in SEEG implantation. RESULTS: Expert raters considered 88.5% of trajectories implantable, with no difference in acceptability between CAP alone and CAP + Priors (p = 0.79). Median (IQR) T1 for CAP to produce complete automated implantation was 4.6 (0.85) min vs. CAP + Priors was 6.3 (2.6) min (p = 0.03). There was no significant difference in T2 (time to complete surgeon-edited plan): CAP median (IQR) 105 (22) min, and CAP + Priors median (IQR) 96 (68) min (p = 0.92). The CAP + Priors risk score was significantly lower than that for the previously actually implanted trajectories for the 11 plans analyzed (p = 0.004), and no different from CAP alone planning. A significant reduction was observed in manual adjustments required with CAP + Priors in the cingulate gyrus. CONCLUSION: Using spatial priors from previous implantations enhances SEEG CAP and increases the granularity of trajectory planning. This approach facilitates more standardized planning and allows for the incorporation of experience from multiple expert centers, decreasing the risk of the resultant trajectories and reducing the proportion of trajectories that require manual planning without significantly increasing planning time.
date: 2025
date_type: published
publisher: Frontiers Media SA
official_url: https://doi.org/10.3389/fneur.2025.1514442
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2366179
doi: 10.3389/fneur.2025.1514442
lyricists_name: O'Keeffe, Aidan
lyricists_id: AGOKE34
actors_name: O'Keeffe, Aidan
actors_id: AGOKE34
actors_role: owner
full_text_status: public
publication: Frontiers in Neurology
volume: 16
article_number: 1514442
citation:        Dasgupta, Debayan;    Elliott, Cameron A;    O’Keeffe, Aidan G;    Rodionov, Roman;    Li, Kuo;    Vakharia, Vejay N;    Mirza, Farhan A;                             ... Duncan, John S; + view all <#>        Dasgupta, Debayan;  Elliott, Cameron A;  O’Keeffe, Aidan G;  Rodionov, Roman;  Li, Kuo;  Vakharia, Vejay N;  Mirza, Farhan A;  Tahir, M Zubair;  Tisdall, Martin M;  Miserocchi, Anna;  McEvoy, Andrew W;  Ourselin, Sebastien;  Sparks, Rachel E;  Duncan, John S;   - view fewer <#>    (2025)    Computer-assisted stereoelectroencephalography planning: center-specific priors enhance planning.                   Frontiers in Neurology , 16     , Article 1514442.  10.3389/fneur.2025.1514442 <https://doi.org/10.3389/fneur.2025.1514442>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205642/7/O%27Keeffe_Computer-assisted%20stereoelectroencephalography%20planning_VoR.pdf