eprintid: 10205636
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/20/56/36
datestamp: 2025-03-05 14:33:28
lastmod: 2025-03-05 14:33:28
status_changed: 2025-03-05 14:33:28
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Moore, Elizabeth
creators_name: Stone, Philip
creators_name: Alizadeh, Ayda
creators_name: Sangha, Jaspreet
creators_name: Das, Saranya
creators_name: Arshanapalli, Shraddha
creators_name: Quint, Jennifer K
title: Validation of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Recording in Electronic Health Records: A Systematic Review
ispublished: inpress
divisions: UCL
divisions: B02
divisions: D12
divisions: G20
keywords: acute exacerbation of COPD, AECOPD, COPD, electronic health records
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: OBJECTIVE: Acute exacerbations of COPD (AECOPD) can have severe impacts on patients with the disease and a heavy burden on healthcare resources. Electronic health records (EHRs) are a valuable resource for identifying cases of AECOPD and research. Studies have attempted to validate case definitions of AECOPD and this review aimed to summarise validated AECOPD definitions in EHRs, and to provide guidance on the best algorithms to use to ensure accurate cohorts of AECOPD cases are available for researchers using EHRs. METHODS: MEDLINE and Embase were searched and studies that met the inclusion criteria were reviewed by ≥2 reviewers. Data extracted included the algorithms used to identify AECOPD, the reference standards used to compare against the algorithm, and measures of validity. The risk of bias was assessed using QUADAS-2 adapted for this review. RESULTS: Out of 2,784 studies found by the search strategy, 12 met the inclusion criteria. The clinical terminology used to build algorithms to detect AECOPD included codes from the International Statistical Classification of Diseases and Related Health Problems (ICD) 9th and 10th editions (ICD-9 and ICD-10), along with Read codes from UK general practices. AECOPD can be identified within EHRs using validated definitions, however the validity of AECOPD definitions vary considerably depending on the algorithm used and the settings they are applied in. CONCLUSION: Although there are validated definitions that can be used to identify AECOPD, there is no clear consensus on which provides the highest validity or the most sensitive and specific definition to use.
date: 2025-02-05
date_type: published
publisher: COPD Foundation
official_url: https://doi.org/10.15326/jcopdf.2024.0577
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2359095
doi: 10.15326/jcopdf.2024.0577
medium: Print-Electronic
lyricists_name: Stone, Philip
lyricists_id: PSTON34
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Chronic Obstructive Pulmonary Diseases
event_location: United States
citation:        Moore, Elizabeth;    Stone, Philip;    Alizadeh, Ayda;    Sangha, Jaspreet;    Das, Saranya;    Arshanapalli, Shraddha;    Quint, Jennifer K;      (2025)    Validation of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Recording in Electronic Health Records: A Systematic Review.                   Chronic Obstructive Pulmonary Diseases        10.15326/jcopdf.2024.0577 <https://doi.org/10.15326/jcopdf.2024.0577>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205636/1/JCOPDF-2024-0577-InPress.pdf