eprintid: 10205518
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/20/55/18
datestamp: 2025-03-04 09:44:30
lastmod: 2025-03-04 09:44:30
status_changed: 2025-03-04 09:44:30
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Guarascio, Rosellina
creators_name: Cheetham, Michael E
title: Light as a Mediator of Acute and Chronic Retina Degeneration
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D08
keywords: AMD, Animal models, Light damage, Photoreceptors cell death, Retinoids cycle, Rhodopsin, Sector RP
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: In age-related macula dystrophy (AMD) and some forms of inherited retinal dystrophies (IRDs), blindness is caused by the loss of photoreceptors and retinal pigment epithelium (RPE) cells. This process can be exacerbated by genetic and environmental risk factors, including exposure of the retina to bright light. Several light damage models have been developed and have proved to be powerful tools to study retinal degeneration. These models have enabled the investigation of common mechanisms of cell death and inflammation, as well as the identification of therapeutic targets and the assessment of potential new therapies against retinal degeneration. Here, we discuss the principal mechanisms of light-induced toxicity and highlight how this has been used in the development of therapeutic approaches to treat AMD and IRDs.
date: 2025-02-11
date_type: published
publisher: Kluwer
official_url: https://doi.org/10.1007/978-3-031-76550-6_41
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2362706
doi: 10.1007/978-3-031-76550-6_41
medium: Print
lyricists_name: Cheetham, Michael
lyricists_name: Guarascio, Rosellina
lyricists_id: MECHE52
lyricists_id: RGUAR59
actors_name: Guarascio, Rosellina
actors_id: RGUAR59
actors_role: owner
full_text_status: restricted
publication: Advances in Experimental Medicine and Biology
volume: 1468
pagerange: 247-251
event_location: United States
issn: 0065-2598
citation:        Guarascio, Rosellina;    Cheetham, Michael E;      (2025)    Light as a Mediator of Acute and Chronic Retina Degeneration.                   Advances in Experimental Medicine and Biology , 1468    pp. 247-251.    10.1007/978-3-031-76550-6_41 <https://doi.org/10.1007/978-3-031-76550-6_41>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205518/1/RDXX_Light%20as%20a%20mediator%20of%20acute%20and%20chronic%20retina%20degeneration_Guarascio%26Cheetham.pdf