TY  - JOUR
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
VL  - 1468
SP  - 247
JF  - Advances in Experimental Medicine and Biology
A1  - Guarascio, Rosellina
A1  - Cheetham, Michael E
UR  - https://doi.org/10.1007/978-3-031-76550-6_41
SN  - 0065-2598
TI  - Light as a Mediator of Acute and Chronic Retina Degeneration
AV  - restricted
Y1  - 2025/02/11/
EP  - 251
KW  - AMD
KW  -  Animal models
KW  -  Light damage
KW  -  Photoreceptors cell death
KW  -  Retinoids cycle
KW  -  Rhodopsin
KW  -  Sector RP
N2  - In age-related macula dystrophy (AMD) and some forms of inherited retinal dystrophies (IRDs), blindness is caused by the loss of photoreceptors and retinal pigment epithelium (RPE) cells. This process can be exacerbated by genetic and environmental risk factors, including exposure of the retina to bright light. Several light damage models have been developed and have proved to be powerful tools to study retinal degeneration. These models have enabled the investigation of common mechanisms of cell death and inflammation, as well as the identification of therapeutic targets and the assessment of potential new therapies against retinal degeneration. Here, we discuss the principal mechanisms of light-induced toxicity and highlight how this has been used in the development of therapeutic approaches to treat AMD and IRDs.
ID  - discovery10205518
PB  - Kluwer
ER  -