eprintid: 10205450
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/20/54/50
datestamp: 2025-02-28 11:48:29
lastmod: 2025-02-28 11:48:29
status_changed: 2025-02-28 11:48:29
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Van Emmenis, L
creators_name: Mòdol-Caballero, G
creators_name: Harford-Wright, E
creators_name: Power, A
creators_name: Cattin, AL
creators_name: White, IJ
creators_name: Casal, G
creators_name: Boal-Carvalho, I
creators_name: Bennett, CL
creators_name: Lloyd, AC
title: Identification of CCL3 as a Schwann cell chemotactic factor essential for nerve regeneration
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: C10
divisions: D19
divisions: G98
divisions: D77
keywords: CCL3, CP: Cell biology, CP: Neuroscience, Schwann cells, chemotaxis, macrophages, migration, nerve injury, neuromas, pain, peripheral nerves, regeneration
note: Copyright © 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
abstract: Peripheral nerves regenerate following injury, in contrast to those of the central nervous system. This involves the collective migration of Schwann cell (SC) cords, which transport regrowing axons across the wound site. The SC cords migrate along a newly formed vasculature, which bridges the wound site in response to vascular endothelial growth factor, secreted by hypoxic macrophages. However, the directional signals by which SC cords navigate the long distances across the wound, in the absence of those that guide axons during development, remain unknown. Here, we identify CCL3 as the SC chemotactic factor, secreted by hypoxic macrophages, responsible for this process. We show that CCL3 promotes collective SC migration and axonal regrowth in vivo and, using genetic mouse models and widely used CCL3 inhibitors, that CCL3 is essential for effective nerve regeneration. These findings have therapeutic implications for both promoting nerve repair and inhibiting the aberrant nerve growth associated with trauma and disease.
date: 2025-02-25
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.celrep.2025.115322
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2363085
doi: 10.1016/j.celrep.2025.115322
medium: Print-Electronic
pii: S2211-1247(25)00093-2
lyricists_name: Lloyd, Alison
lyricists_name: Bennett, Clare
lyricists_name: Casal, Giulia
lyricists_id: ACLLO84
lyricists_id: CBENN26
lyricists_id: GCASA44
actors_name: Lloyd, Alison
actors_id: ACLLO84
actors_role: owner
full_text_status: public
publication: Cell Reports
volume: 44
number: 2
article_number: 115322
event_location: United States
issn: 2639-1856
citation:        Van Emmenis, L;    Mòdol-Caballero, G;    Harford-Wright, E;    Power, A;    Cattin, AL;    White, IJ;    Casal, G;             ... Lloyd, AC; + view all <#>        Van Emmenis, L;  Mòdol-Caballero, G;  Harford-Wright, E;  Power, A;  Cattin, AL;  White, IJ;  Casal, G;  Boal-Carvalho, I;  Bennett, CL;  Lloyd, AC;   - view fewer <#>    (2025)    Identification of CCL3 as a Schwann cell chemotactic factor essential for nerve regeneration.                   Cell Reports , 44  (2)    , Article 115322.  10.1016/j.celrep.2025.115322 <https://doi.org/10.1016/j.celrep.2025.115322>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205450/1/Van%20Emmenis%20el%20al%20published%20PDF.pdf