eprintid: 10205288 rev_number: 9 eprint_status: archive userid: 699 dir: disk0/10/20/52/88 datestamp: 2025-02-26 08:08:11 lastmod: 2025-02-26 08:08:11 status_changed: 2025-02-26 08:08:11 type: article metadata_visibility: show sword_depositor: 699 creators_name: Yu, Dongmei creators_name: Tang, Zhen creators_name: Bao, Shusen creators_name: Guo, Shuo creators_name: Chen, Changchen creators_name: Wu, Qi creators_name: Wang, Mo creators_name: Zheng, Zenghui creators_name: Cao, Pengfei creators_name: Xu, Bin creators_name: Wu, Hao creators_name: Wang, Ning creators_name: Huang, Hai creators_name: Liu, Chaozong creators_name: Li, Xiaokang creators_name: Guo, Zheng title: Immunoregulatory Neuro-Vascularized Osseointegration Driven by Different Nano-Morphological CaTiO3 Bioactive Coatings on Porous Titanium Alloy Scaffolds ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D16 divisions: G86 keywords: angiogenesis, calcium titanate (CaTiO3), immunoregulatory osseointegration, nanomorphology, neurogenesis note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Up to now, how to implement the optimal regenerative repair of large load-bearing bone defects using artificial bone prosthesis remains to be an enormous challenge in clinical practice. Titanium-based alloys, especially Ti6Al4V, are applied as artificial bone grafts due to their favorable mechanical property and biocompatibility, assisted by personalized customization of 3D-printing to completely match with the bone defect. However, their bioinert peculiarity restricts osteointegration at the interface between bone and titanium-based implants and bone growth into porous titanium-based scaffolds, for lack of bone regeneration with the aid of blood vessels and neural networks. Of note, ample blood delivery and integral innervation are pivotal to the survival of artificially tissue-engineered bones. Herein, the functionalized surface of 3D printed titanium alloy scaffolds driven immunoregulatory neuro-vascularized osseointegration is delved. Bone-like micro/nano morphology and chemical composition of calcium-rich formula are scrutinized to accelerate the process of bone defect repair, including inflammatory response, angiogenesis, neurogenesis, and osseointegration. Micro/nano-topographic calcium titanate (CaTiO3) coating, especially 10%H2O2-Ca, driven immunoregulatory neuro-vascularized osseointegration is validated and its underlying mechanism is attributed to the signaling pathway of TNF-α /oxidative phosphorylation, providing an effective tactic of the bone tissue-engineered scaffold with surface functionalization-driven immunoregulatory neuro-vascularized osseointegration for clinical large segmental bone defects. date: 2025-02-24 date_type: published official_url: https://doi.org/10.1002/adhm.202404647 full_text_type: other language: eng verified: verified_manual elements_id: 2364217 doi: 10.1002/adhm.202404647 medium: Print-Electronic lyricists_name: Liu, Chaozong lyricists_id: CLIUX47 actors_name: Liu, Chaozong actors_id: CLIUX47 actors_role: owner funding_acknowledgements: 2023YFC2412600 [National Key Research and Development Program of China]; 82372124 [National Natural Science Foundation of China]; 82402479 [National Natural Science Foundation of China]; 51871239 [National Natural Science Foundation of China]; 51771227 [National Natural Science Foundation of China]; 17QNP021 [Incubation Project of the Army's Medical Technology Youth Cultivation Program of China]; 2020ZFC002 [Everest Program of the Air Force Medical University]; 2022YFJH004 [Phoenix Introduction Plan Talent Startover Project of Tangdu Hospital, Fourth Military Medical University]; EP/T517793/1 [Engineering and Physical Sciences Research Council via DTP CASE Programme] full_text_status: restricted publication: Advanced Healthcare Materials article_number: e2404647 event_location: Germany issn: 2192-2640 citation: Yu, Dongmei; Tang, Zhen; Bao, Shusen; Guo, Shuo; Chen, Changchen; Wu, Qi; Wang, Mo; ... Guo, Zheng; + view all <#> Yu, Dongmei; Tang, Zhen; Bao, Shusen; Guo, Shuo; Chen, Changchen; Wu, Qi; Wang, Mo; Zheng, Zenghui; Cao, Pengfei; Xu, Bin; Wu, Hao; Wang, Ning; Huang, Hai; Liu, Chaozong; Li, Xiaokang; Guo, Zheng; - view fewer <#> (2025) Immunoregulatory Neuro-Vascularized Osseointegration Driven by Different Nano-Morphological CaTiO3 Bioactive Coatings on Porous Titanium Alloy Scaffolds. Advanced Healthcare Materials , Article e2404647. 10.1002/adhm.202404647 <https://doi.org/10.1002/adhm.202404647>. (In press). document_url: https://discovery.ucl.ac.uk/id/eprint/10205288/1/Liu_nano-morphological%20CaTiO3%20bioactive%20coatings%20on%20porous%20titanium%20alloy%20scaffolds.pdf