@article{discovery10205244,
           title = {Simple Accessible Clemastine Fumarate Analogues as Effective Antileishmanials},
            note = {{\copyright} The Author(s), 2025. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/3.0/},
       publisher = {Royal Society of Chemistry (RSC)},
            year = {2025},
         journal = {RSC Medicinal Chemistry},
          author = {Charlton, Rebecca and Escrivani, Douglas and Brown, Christopher and Thota, Niranjan and de Sousa Agostino, Victor and Porta, Exequiel and Avkiran, Timur and Merritt, Andrew T and Denny, Paul W and Rossi-Bergmann, Bartira and Steel, PG},
        abstract = {Current therapeutic options for leishmaniasis are severely limited, highlighting an urgent need to develop more effective and less toxic drugs to combat a major global public health challenge. Clemastine fumarate displays good levels of antileishmanial efficacy, but further optimisation is challenged by its difficult synthesis. Here, we demonstrate that simple N-linked analogues are easier to access, can exhibit higher selectivity and show comparable efficacy in a mouse model of Leishmania amazonensis infection.},
        keywords = {Leishmaniasis, Clemastine Fumarate, Inositol Phosphoryl Ceramide Synthase, Enantioselective Synthesis, Drug Discovery},
            issn = {2632-8682},
             url = {https://doi.org/10.1039/D4MD01004C}
}