eprintid: 10205184
rev_number: 6
eprint_status: archive
userid: 699
dir: disk0/10/20/51/84
datestamp: 2025-02-24 12:41:29
lastmod: 2025-02-24 12:41:29
status_changed: 2025-02-24 12:41:29
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Charlton, Colleen E
creators_name: Hauke, Daniel J
creators_name: Wobmann, Michelle
creators_name: de Bock, Renate
creators_name: Andreou, Christina
creators_name: Borgwardt, Stefan
creators_name: Roth, Volker
creators_name: Diaconescu, Andreea O
title: Localizing hierarchical prediction errors and precisions during an oddball task with volatility: Computational insights and relationship with psychosocial functioning in healthy individuals
ispublished: pub
divisions: UCL
divisions: B04
divisions: F48
keywords: Sensory learning, hierarchical Gaussian filter, predictive coding, EEG, functioning
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abstract: The auditory mismatch negativity (MMN) has been widely used to investigate deficits in early auditory information processing, particularly in psychosis. Predictive coding theories suggest that impairments in sensory learning may arise from disturbances in hierarchical message passing, likely due to aberrant precision-weighting of prediction errors (PEs). This study employed a modified auditory oddball paradigm with varying phases of stability and volatility to disentangle the impact of hierarchical PEs on auditory MMN generation in 43 healthy controls (HCs). Single-trial EEG data were modeled with a hierarchical Bayesian model of learning to identify neural correlates of low-level PEs about tones and high-level PEs about environmental volatility. Our analysis revealed a reduced expression of the auditory MMN in volatile compared to stable phases of the paradigm. Additionally, lower Global Functioning (GF): Social scores were associated with a reduced difference waveform at 332 ms after stimulus presentation across the entire MMN paradigm. Further analysis revealed that this association was present during the volatile phase but not the stable phase of the paradigm. Source reconstruction suggested that the association between the stable difference waveform and psychosocial functioning originated in the left superior temporal gyrus. Finally, we found significant EEG signatures of both low- and high-level PEs and precision ratios. Our findings highlight the value of computational models in understanding the neural mechanisms involved in early auditory information processing and their connection to psychosocial functioning.
date: 2025-02-03
date_type: published
publisher: MIT Press
official_url: https://doi.org/10.1162/imag_a_00461
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2363932
doi: 10.1162/imag_a_00461
lyricists_name: Hauke, Daniel
lyricists_id: DHAUK94
actors_name: Hauke, Daniel
actors_id: DHAUK94
actors_role: owner
full_text_status: public
publication: Imaging Neuroscience
volume: 3
article_number: imag_a_00461
citation:        Charlton, Colleen E;    Hauke, Daniel J;    Wobmann, Michelle;    de Bock, Renate;    Andreou, Christina;    Borgwardt, Stefan;    Roth, Volker;           Charlton, Colleen E;  Hauke, Daniel J;  Wobmann, Michelle;  de Bock, Renate;  Andreou, Christina;  Borgwardt, Stefan;  Roth, Volker;  Diaconescu, Andreea O;   - view fewer <#>    (2025)    Localizing hierarchical prediction errors and precisions during an oddball task with volatility: Computational insights and relationship with psychosocial functioning in healthy individuals.                   Imaging Neuroscience , 3     , Article imag_a_00461.  10.1162/imag_a_00461 <https://doi.org/10.1162/imag_a_00461>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205184/1/imag_a_00461.pdf