eprintid: 10205158
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/51/58
datestamp: 2025-02-24 12:24:27
lastmod: 2025-02-24 12:24:27
status_changed: 2025-02-24 12:24:27
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: McGregor, Thomas
creators_name: Carr, Ewan
creators_name: Barry, Tom
creators_name: Catarino, Ana
creators_name: Craske, Michelle G
creators_name: Davies, Molly R
creators_name: Kerr, Tim
creators_name: Krebs, Georgina
creators_name: MacDonald, Bridie
creators_name: Purves, Kirstin L
creators_name: Skelton, Megan
creators_name: Thompson, Ellen J
creators_name: Breen, Gerome
creators_name: Hirsch, Colette R
creators_name: Eley, Thalia C
title: Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F66
keywords: Fear conditioning; Fear extinction; Cognitive-behavioural therapy; Online; Treatment
outcome; Anxiety
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Despite the widespread use of cognitive-behavioural therapy (CBT), only about half of patients respond favourably. Understanding whether relevant psychological processes are associated with treatment response could help identify patients at risk of non-response prior to treatment and improve their outcomes by enabling clinicians to tailor interventions accordingly. Fear conditioning tasks are a valuable tool for studying the learning processes associated with anxiety disorders and their treatment. This study examined associations between outcomes from a remote fear conditioning task and responses to internet-based CBT.
Anxious adults (n = 112) completed a fear conditioning task before receiving internet-based CBT. Participants rated their expectancy of an aversive noise (unconditioned stimulus; US) in response to a reinforced conditional stimulus (CS+) and a nonreinforced conditional stimulus (CS-) during acquisition, followed by extinction where neither stimulus was reinforced. Anxiety symptoms were assessed before each CBT session. Linear regression models indicated no significant association between mean US-expectancy ratings for 'safe' stimuli (acquisition CS- and extinction CS+) and change in anxiety across treatment. These findings contribute to the mixed literature on fear conditioning's role in treatment outcomes, highlighting the need for further research to elucidate the complex interplay between fear conditioning processes and response to CBT in anxiety disorders.
date: 2025-02
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.brat.2025.104705
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2363802
doi: 10.1016/j.brat.2025.104705
lyricists_name: Krebs, Georgina
lyricists_id: GKREB33
actors_name: Krebs, Georgina
actors_id: GKREB33
actors_role: owner
full_text_status: restricted
publication: Behaviour Research and Therapy
volume: 187
article_number: 104705
issn: 0005-7967
citation:        McGregor, Thomas;    Carr, Ewan;    Barry, Tom;    Catarino, Ana;    Craske, Michelle G;    Davies, Molly R;    Kerr, Tim;                                 ... Eley, Thalia C; + view all <#>        McGregor, Thomas;  Carr, Ewan;  Barry, Tom;  Catarino, Ana;  Craske, Michelle G;  Davies, Molly R;  Kerr, Tim;  Krebs, Georgina;  MacDonald, Bridie;  Purves, Kirstin L;  Skelton, Megan;  Thompson, Ellen J;  Breen, Gerome;  Hirsch, Colette R;  Eley, Thalia C;   - view fewer <#>    (2025)    Self-report measures of fear learning and extinction and their association with internet-based cognitive behavioural therapy outcome.                   Behaviour Research and Therapy , 187     , Article 104705.  10.1016/j.brat.2025.104705 <https://doi.org/10.1016/j.brat.2025.104705>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205158/3/Krebs_PORT_manuscript-draft_post_review.pdf