TY  - JOUR
EP  - 352
N2  - Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by experimental, epidemiological, neuropathological and genetic studies suggest a pathological role for innate and adaptive immune activation in this disease. Here, we review the cell types and pathological mechanisms involved in disease development as well as the influence of genetics and lifestyle factors. Given the decade-long preclinical stage of Alzheimer disease, these mechanisms and their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear definition of their temporal and topographical nature. We will also discuss new therapeutic strategies for targeting neuroinflammation, which are now entering the clinic and showing promise for patients.
UR  - https://doi.org/10.1038/s41577-024-01104-7
VL  - 25
A1  - Heneka, Michael T
A1  - Van der Flier, Wiesje M
A1  - Jessen, Frank
A1  - Hoozemanns, Jeroen
A1  - Thal, Dietmar Rudolf
A1  - Boche, Delphine
A1  - Brosseron, Frederic
A1  - Teunissen, Charlotte
A1  - Zetterberg, Henrik
A1  - Jacobs, Andreas H
A1  - Edison, Paul
A1  - Ramirez, Alfredo
A1  - Cruchaga, Carlos
A1  - Lambert, Jean-Charles
A1  - Laza, Agustin Ruiz
A1  - Sanchez-Mut, Jose Vicente
A1  - Fischer, Andre
A1  - Castro-Gomez, Sergio
A1  - Stein, Thor D
A1  - Kleineidam, Luca
A1  - Wagner, Michael
A1  - Neher, Jonas J
A1  - Cunningham, Colm
A1  - Singhrao, Sim K
A1  - Prinz, Marco
A1  - Glass, Christopher K
A1  - Schlachetzki, Johannes CM
A1  - Butovsky, Oleg
A1  - Kleemann, Kilian
A1  - De Jaeger, Philip L
A1  - Scheiblich, Hannah
A1  - Brown, Guy C
A1  - Landreth, Gary
A1  - Moutinho, Miguel
A1  - Grutzendler, Jaime
A1  - Gomez-Nicola, Diego
A1  - McManus, Róisín M
A1  - Andreasson, Katrin
A1  - Ising, Christina
A1  - Karabag, Deniz
A1  - Baker, Darren J
A1  - Liddelow, Shane A
A1  - Verkhratsky, Alexei
A1  - Tansey, Malu
A1  - Monsonego, Alon
A1  - Aigner, Ludwig
A1  - Dorothée, Guillaume
A1  - Nave, Klaus-Armin
A1  - Simons, Mikael
A1  - Constantin, Gabriela
A1  - Rosenzweig, Neta
A1  - Pascual, Alberto
A1  - Petzold, Gabor C
A1  - Kipnis, Jonathan
A1  - Venegas, Carmen
A1  - Colonna, Marco
A1  - Walter, Jochen
A1  - Tenner, Andrea J
A1  - O'Banion, M Kerry
A1  - Steinert, Joern R
A1  - Feinstein, Douglas L
A1  - Sastre, Magdalena
A1  - Bhaskar, Kiran
A1  - Hong, Soyon
A1  - Schafer, Dorothy P
A1  - Golde, Todd
A1  - Ransohoff, Richard M
A1  - Morgan, David
A1  - Breitner, John
A1  - Mancuso, Renzo
A1  - Riechers, Sean-Patrick
ID  - discovery10205096
PB  - Nature Publishing Group
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
Y1  - 2025/05//
TI  - Neuroinflammation in Alzheimer disease
JF  - Nature Reviews Immunology
AV  - public
KW  - Neuroimmunology
KW  -  Neurological disorders
SP  - 321
SN  - 1474-1733
ER  -