eprintid: 10205094
rev_number: 8
eprint_status: archive
userid: 699
dir: disk0/10/20/50/94
datestamp: 2025-02-21 12:51:00
lastmod: 2025-02-21 12:51:55
status_changed: 2025-02-21 12:51:00
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Shanks, Gabriella
creators_name: Grandjean, Louis
title: Carbapenem-Resistant Infections in Neonates and Children in Latin America: A Literature Review
ispublished: pub
divisions: UCL
divisions: B02
divisions: D13
divisions: G24
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Carbapenems are broad-spectrum beta-lactam antibiotics that are increasingly being used worldwide to treat multidrug-resistant infections, but since their introduction, carbapenem resistance has emerged. This phenomenon has been well documented in the adult population, but there is a paucity of evidence from the neonatal and pediatric populations. A literature search of carbapenem-resistant infections in Latin American neonates and children was conducted via PubMed/Medline and SCOPUS: 551 titles were screened, and 17 articles were included in the review. The most commonly reported predominant isolate was Klebsiella pneumoniae (11 of 17 studies). Genotypic data were available in 10 of 17 studies, and the KPC gene was the most commonly reported resistance gene. The mortality rate ranged from 13% to 52.6%. Carbapenem-resistant infections are prevalent in children and neonates in Latin America and are associated with high rates of mortality, highlighting the need for enhanced antimicrobial stewardship and surveillance within these populations.
date: 2025-01-08
date_type: published
publisher: American Society of Tropical Medicine and Hygiene
official_url: https://doi.org/10.4269/ajtmh.24-0422
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2358005
doi: 10.4269/ajtmh.24-0422
medium: Electronic-Print
pii: tpmd240422
lyricists_name: Grandjean, Louis
lyricists_id: LGRAN67
actors_name: Grandjean, Louis
actors_id: LGRAN67
actors_role: owner
full_text_status: public
publication: The American Journal of Tropical Medicine and Hygiene
volume: 112
number: 1
pagerange: 26-29
event_location: United States
issn: 0002-9637
citation:        Shanks, Gabriella;    Grandjean, Louis;      (2025)    Carbapenem-Resistant Infections in Neonates and Children in Latin America: A Literature Review.                   The American Journal of Tropical Medicine and Hygiene , 112  (1)   pp. 26-29.    10.4269/ajtmh.24-0422 <https://doi.org/10.4269/ajtmh.24-0422>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205094/1/tpmd-article-10.4269-ajtmh.24-0422.pdf