eprintid: 10205014
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/20/50/14
datestamp: 2025-02-20 12:17:07
lastmod: 2025-02-20 12:17:07
status_changed: 2025-02-20 12:17:07
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Liao, Xinying
creators_name: Feng, Xiaoyi
creators_name: Xiao, Ziyi
creators_name: Williams, Gareth R
creators_name: Huang, Xiaozhi
creators_name: Shi, Yunyun
creators_name: Qin, Hui
creators_name: Liu, Yang
title: Multifunctional phenylboric acid modified carboxymethyl chitosan based hydrogel crosslinked by tannic acid
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: Chitosan; Tannic acid; Hydrogel
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Hydrogels prepared from natural polysaccharide, such as chitosan, have attracted much attention owing to their advantageous physicochemical properties and functions. Therefore, it is of great significance to develop novel crosslinking and preparation methods for hydrogels. Here, a class of multifunctional chitosan-based (CBT) hydrogels were prepared from 3-carboxy-5-nitrophenylboronic acid (PBA) modified carboxymethyl chitosan (CMCS) and tannic acid (TA) by double crosslinking of borate ester and hydrogen bonds. They could rapidly gel within 1 min through physical blending under physiological conditions. They had good physicochemical properties such as injectability, plasticity, self-healing, swelling and biodegradability. They also exhibited the inherent viscoelastic behavior of hydrogels and had a maximum compressive strength of up to 0.31 Mpa. Moreover, they had excellent biocompatibility, hemostatic ability and antioxidant ability. Their maximum antibacterial rate against S. aureus and E.coli were up to 85.22 ± 2.73 % and 48.50 ± 1.04 %, respectively. They could be loaded with the model drug curcumin through borate ester bond and achieve glucose-sensitive controlled release. Preliminary in vivo experiments also showed good biosafety and degradability. Therefore, the multifunctional hydrogels provided a new approach for the design of polysaccharide-based hydrogels, and could potentially be applied in wound repair, drug delivery and other biomedical fields.
date: 2025-04
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.ijbiomac.2025.140958
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2361637
doi: 10.1016/j.ijbiomac.2025.140958
medium: Print-Electronic
pii: S0141-8130(25)01507-7
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: restricted
publication: International Journal of Biological Macromolecules
volume: 304
number: Part 2
article_number: 140958
event_location: Netherlands
issn: 0141-8130
citation:        Liao, Xinying;    Feng, Xiaoyi;    Xiao, Ziyi;    Williams, Gareth R;    Huang, Xiaozhi;    Shi, Yunyun;    Qin, Hui;           Liao, Xinying;  Feng, Xiaoyi;  Xiao, Ziyi;  Williams, Gareth R;  Huang, Xiaozhi;  Shi, Yunyun;  Qin, Hui;  Liu, Yang;   - view fewer <#>    (2025)    Multifunctional phenylboric acid modified carboxymethyl chitosan based hydrogel crosslinked by tannic acid.                   International Journal of Biological Macromolecules , 304  (Part 2)    , Article 140958.  10.1016/j.ijbiomac.2025.140958 <https://doi.org/10.1016/j.ijbiomac.2025.140958>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10205014/1/Multifunctional%20phenylboric%20acid%20modified%20carboxymethyl%20chitosan%20based%20hydrogel%20crosslinked%20by%20tannic%20acid..pdf