eprintid: 10204910
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/49/10
datestamp: 2025-02-18 09:54:40
lastmod: 2025-02-18 09:54:40
status_changed: 2025-02-18 09:54:40
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Aydin, S
creators_name: Tekinalp, SG
creators_name: Tuzcu, B
creators_name: Cam, F
creators_name: Sevik, MO
creators_name: Tatar, E
creators_name: Kalaskar, D
creators_name: Cam, ME
title: The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D16
divisions: G86
keywords: AMP-activated protein kinase,
AMPK activators,
AMPK signalling,
Type 2 diabetes mellitus,
Diabetic complication
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within cells and controls cellular metabolism. Over the past decade, numerous studies have highlighted the remarkable potential of AMPK and its activators in treating T2DM. Key compounds, including biguanides (e.g., metformin), thiazolidinediones, phenolic compounds (e.g., resveratrol), and AICAR, have demonstrated the ability to improve insulin sensitivity, enhance glucose uptake in skeletal muscle, reduce hepatic glucose production, and improve glycemic control. Additionally, AMPK activators have shown promising effects on lipid metabolism, inflammation, and oxidative stress, which are critical factors in the pathogenesis of T2DM. The activation of AMPK by natural products and synthetic drug candidates represents a promising avenue for developing novel treatments targeting T2DM and its complications. This review aims to provide an overview of direct and indirect AMPK activation and its relevance in organs implicated in the development of T2DM.
date: 2025-01-01
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.obmed.2024.100577
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2345666
doi: 10.1016/j.obmed.2024.100577
lyricists_name: Kalaskar, Deepak
lyricists_id: DKALA41
actors_name: Kalaskar, Deepak
actors_id: DKALA41
actors_role: owner
full_text_status: restricted
publication: Obesity Medicine
volume: 53
article_number: 100577
issn: 2451-8476
citation:        Aydin, S;    Tekinalp, SG;    Tuzcu, B;    Cam, F;    Sevik, MO;    Tatar, E;    Kalaskar, D;           Aydin, S;  Tekinalp, SG;  Tuzcu, B;  Cam, F;  Sevik, MO;  Tatar, E;  Kalaskar, D;  Cam, ME;   - view fewer <#>    (2025)    The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus.                   Obesity Medicine , 53     , Article 100577.  10.1016/j.obmed.2024.100577 <https://doi.org/10.1016/j.obmed.2024.100577>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10204910/3/Kalaskar_AMPK%20Review%20Article.pdf