TY  - JOUR
ID  - discovery10204910
N2  - Type 2 Diabetes Mellitus (T2DM) is a growing health concern that leads to increased morbidity and mortality rates worldwide. A protein complex called AMP-activated protein kinase (AMPK) regulates energy balance within cells and controls cellular metabolism. Over the past decade, numerous studies have highlighted the remarkable potential of AMPK and its activators in treating T2DM. Key compounds, including biguanides (e.g., metformin), thiazolidinediones, phenolic compounds (e.g., resveratrol), and AICAR, have demonstrated the ability to improve insulin sensitivity, enhance glucose uptake in skeletal muscle, reduce hepatic glucose production, and improve glycemic control. Additionally, AMPK activators have shown promising effects on lipid metabolism, inflammation, and oxidative stress, which are critical factors in the pathogenesis of T2DM. The activation of AMPK by natural products and synthetic drug candidates represents a promising avenue for developing novel treatments targeting T2DM and its complications. This review aims to provide an overview of direct and indirect AMPK activation and its relevance in organs implicated in the development of T2DM.
SN  - 2451-8476
UR  - https://doi.org/10.1016/j.obmed.2024.100577
PB  - Elsevier BV
JF  - Obesity Medicine
KW  - AMP-activated protein kinase
KW  - 
AMPK activators
KW  - 
AMPK signalling
KW  - 
Type 2 diabetes mellitus
KW  - 
Diabetic complication
A1  - Aydin, S
A1  - Tekinalp, SG
A1  - Tuzcu, B
A1  - Cam, F
A1  - Sevik, MO
A1  - Tatar, E
A1  - Kalaskar, D
A1  - Cam, ME
TI  - The role of AMP-activated protein kinase activators on energy balance and cellular metabolism in type 2 diabetes mellitus
Y1  - 2025/01/01/
AV  - restricted
VL  - 53
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
ER  -