eprintid: 10204805 rev_number: 7 eprint_status: archive userid: 699 dir: disk0/10/20/48/05 datestamp: 2025-02-17 10:04:23 lastmod: 2025-02-17 10:04:23 status_changed: 2025-02-17 10:04:23 type: article metadata_visibility: show sword_depositor: 699 creators_name: Schoenaker, Danielle creators_name: Lovegrove, Elizabeth M creators_name: Cassinelli, Emma H creators_name: Hall, Jennifer creators_name: Mcgranahan, Majel creators_name: Mcgowan, Laura creators_name: Carr, Helen creators_name: Alwan, Nisreen A creators_name: Stephenson, Judith creators_name: Godfrey, Keith M title: Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review ispublished: pub divisions: UCL divisions: B02 divisions: D11 divisions: G13 keywords: Science & Technology, Life Sciences & Biomedicine, Primary Health Care, Medicine, General & Internal, General & Internal Medicine, general practice, preconception care, pregnancy, pregnancy outcomes, pre- pregnancy care, primary care, EMERGENCY CONTRACEPTION, ORAL-CONTRACEPTIVES, WOMEN, POPULATION, PREGNANCY, RISK, PREVALENCE, PROVISION, PATTERNS, ENGLAND note: This article is Open Access: CC BY 4.0 licence (http://creativecommons.org/ licences/by/4.0/). abstract: Background Routine primary care data may be a valuable resource for preconception health research and to inform the provision of preconception care. Aim To review how primary care data could provide information on the prevalence of preconception indicators and examine associations with maternal and offspring health outcomes. Design and setting Systematic review of observational studies using UK routine primary care data. Method Literature searches were conducted in March 2023 using five databases to identify observational studies that used national primary care data from individuals aged 15–49 years. Preconception indicators were defined as medical, behavioural, and social factors that may impact future pregnancies; health outcomes included those that may occur during and after pregnancy. Results From 5259 screened records, 42 articles were included. The prevalence of 37 preconception indicator measures was described for female patients, ranging from 0.01% for sickle cell disease to >20% for each of advanced maternal age, previous caesarean section (among those with a recorded pregnancy), overweight, obesity, smoking, depression, and anxiety (irrespective of pregnancy). Few studies reported indicators for male patients (n = 3) or associations with outcomes (n = 5). Most studies had a low risk of bias, but missing data may limit generalisability of the findings. Conclusion The findings demonstrated that routinely collected UK primary care data could be used to identify patients’ preconception care needs. Linking primary care data with health outcomes collected in other datasets is underutilised, but could help to quantify how optimising preconception health and care could reduce adverse outcomes for mothers and children. date: 2025-02-01 date_type: published publisher: ROYAL COLL GENERAL PRACTITIONERS official_url: https://doi.org/10.3399/bjgp.2024.0082 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2292033 doi: 10.3399/BJGP.2024.0082 medium: Electronic-Print pii: BJGP.2024.0082 lyricists_name: Hall, Jennifer lyricists_name: Stephenson, Judith lyricists_name: Schoenaker, Danielle lyricists_id: JAHAL68 lyricists_id: JMSTE16 lyricists_id: DSCHO82 actors_name: Hall, Jennifer actors_id: JAHAL68 actors_role: owner funding_acknowledgements: NIHR302955 [National Institute for Health and Care Research (NIHR) through an NIHR Advanced Fellowship]; NIHR302955 [NIHR Southampton Biomedical Research Centre]; NIHR203319 [NIHR Southampton Biomedical Research Centre]; MC_UU_12011/4 [UK Medical Research Council]; MR/W01498X/1 [UK Medical Research Council]; NF-SI-0515-10042 [NIHR (NIHR Senior Investigator)]; ARUK-PG2022A-008 [Alzheimer's Research UK] full_text_status: public publication: British Journal of General Practice (BJGP) volume: 75 number: 751 pagerange: e129-e136 pages: 8 event_location: England issn: 0960-1643 citation: Schoenaker, Danielle; Lovegrove, Elizabeth M; Cassinelli, Emma H; Hall, Jennifer; Mcgranahan, Majel; Mcgowan, Laura; Carr, Helen; ... Godfrey, Keith M; + view all <#> Schoenaker, Danielle; Lovegrove, Elizabeth M; Cassinelli, Emma H; Hall, Jennifer; Mcgranahan, Majel; Mcgowan, Laura; Carr, Helen; Alwan, Nisreen A; Stephenson, Judith; Godfrey, Keith M; - view fewer <#> (2025) Preconception indicators and associations with health outcomes reported in UK routine primary care data: a systematic review. British Journal of General Practice (BJGP) , 75 (751) e129-e136. 10.3399/BJGP.2024.0082 <https://doi.org/10.3399/BJGP.2024.0082>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10204805/1/Preconception%20indicators%20and%20associations%20with%20health%20outcomes%20reported%20in%20UK%20routine%20primary%20care%20data%20a%20systematic%20review.pdf