@article{discovery10204780,
          volume = {18},
            note = {{\copyright} 2024 The Authors. ChemSusChem published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).},
           title = {On the Valorisation of Chitin-Derived Furans by Milling},
            year = {2025},
       publisher = {WILEY-V C H VERLAG GMBH},
         journal = {ChemSusChem},
           month = {February},
          number = {3},
        abstract = {Chitin-derived furans offer a sustainable alternative feedstock for nitrogen appended aromatic compounds. Herein, we address the challenge of using chitin-derived furans, 3-acetamido-5-acetylfuran (3A5AF) and 3-acetamido-5-furfural aldehyde (3A5F), to favour the formation of exo Diels-Alder adducts and 4-acetylaminophthalimides respectively, using a mechanochemical ball-milling technique. Mechanochemical activation is explored through the synthesis of 7-oxa-norbornene backbones with novel substitution pattern from 3A5AF in yields up to 77 \% and improved exo:endo selectivity compared to solution-phase reactions. The synthesis of 4-acetylaminophthalimides from 3A5F in yields up to 79 \% is also showcased from hydrazone derivatives.},
          author = {Mattioli, Renan Rodini and Santos, Camila Souza and de Souza, Bruna Butke and Branco, Pedro Dominguez and Bolt, Robert RA and Raby-Buck, Sarah E and Cabral, Tadeu Luiz Gomes and Tormena, Claudio F and Browne, Duncan L and Pastre, Julio C},
             url = {https://doi.org/10.1002/cssc.202401584},
        keywords = {Diels-Alder, Hydrazone, Aromatics, Chitin, Mechanochemistry}
}