eprintid: 10204717 rev_number: 22 eprint_status: archive userid: 699 dir: disk0/10/20/47/17 datestamp: 2025-02-13 08:11:41 lastmod: 2025-02-13 08:11:41 status_changed: 2025-02-13 08:11:41 type: article metadata_visibility: show sword_depositor: 699 creators_name: Jordon, Louise Helen creators_name: Ganeshan, Balaji creators_name: Nadeem, Iftikhar creators_name: Hoy, Luke creators_name: Mahdi, Noor creators_name: Porter, Joanna C creators_name: Groves, Ashley creators_name: Win, Thida title: Can FDG-PET/CT imaging be used to predict decline in quality of life in interstitial lung disease? A prospective study of the relationship between FDG uptake and quality of life in a UK outpatient setting ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: K71 divisions: FI6 keywords: Y note: This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. abstract: Background: 18 Fluorine-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) CT imaging has been used in many inflammatory and infectious conditions to differentiate areas of increased metabolic activity. FDG uptake differs between areas of normal lung parenchyma and interstitial lung disease (ILD). Objectives: In this study, we investigated whether FDG-PET/CT parameters were associated with a change in the quality of life (QoL) in patients with ILD over 4 years of follow-up. Methods: Patients underwent PET-CT imaging at diagnosis and were followed up with annual QoL assessment using the St George's Respiratory Questionnaire (SGRQ) until death or 4 years of follow-up. Maximum standard uptake value (SUVmax) and Tissue-to-Background Ratio (TBR) were assessed against SGRQ overall and subscale scores. Results: 193 patients (94 patients in the idiopathic pulmonary fibrosis (IPF) subgroup and 99 patients in the non-IPF subgroup) underwent baseline FDG-PET/CT imaging and QoL assessment. Weak-to-moderate correlation was observed between baseline SUVmax and SGRQ scores in both ILD subgroups. No relationship was observed between baseline SUVmax or TBR and change in SGRQ scores over 4 years of follow-up. In the IPF subgroup, surviving patients reported a decline in QoL at 4 years post diagnosis whereas an improvement in QoL was seen in surviving patients with non-IPF ILD. Conclusions: Weak-to-moderate positive correlation between baseline SUVmax and SGRQ scores was observed in both ILD subgroups (IPF:r s =0.187, p=0.047, non-IPF: r s =0.320, p=0.001). However, baseline SUVmax and TBR were not associated with change in QoL in patients with IPF and non-IPF ILD over 4 years of follow-up. At 4 years post diagnosis, surviving patients with IPF reported declining QoL whereas improvement was seen in patients with ILD who did not have IPF. date: 2024-05-30 date_type: published publisher: BMJ PUBLISHING GROUP official_url: https://doi.org/10.1136/bmjopen-2023-081103 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2284376 doi: 10.1136/bmjopen-2023-081103 medium: Electronic pii: bmjopen-2023-081103 lyricists_name: Porter, Joanna lyricists_name: Groves, Ashley lyricists_name: Ganeshan, Balaji lyricists_id: JCMPO43 lyricists_id: AGROV91 lyricists_id: BGANE86 actors_name: Groves, Ashley actors_id: AGROV91 actors_role: owner funding_acknowledgements: [Department of Health's NIHR Biomedical Research Centre's funding scheme] full_text_status: public publication: BMJ OPEN volume: 14 number: 5 article_number: e081103 pages: 9 event_location: England issn: 2044-6055 citation: Jordon, Louise Helen; Ganeshan, Balaji; Nadeem, Iftikhar; Hoy, Luke; Mahdi, Noor; Porter, Joanna C; Groves, Ashley; Jordon, Louise Helen; Ganeshan, Balaji; Nadeem, Iftikhar; Hoy, Luke; Mahdi, Noor; Porter, Joanna C; Groves, Ashley; Win, Thida; - view fewer <#> (2024) Can FDG-PET/CT imaging be used to predict decline in quality of life in interstitial lung disease? A prospective study of the relationship between FDG uptake and quality of life in a UK outpatient setting. BMJ OPEN , 14 (5) , Article e081103. 10.1136/bmjopen-2023-081103 <https://doi.org/10.1136/bmjopen-2023-081103>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10204717/1/Groves_e081103.full.pdf