<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10204684> .
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<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/title> "Baseline Characteristics of the DISCOVER CKD Prospective Cohort"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/abstract> "INTRODUCTION: Real-world data from patients with chronic kidney disease (CKD) are limited, particularly regarding clinical management, treatment patterns and health-related quality of life (HRQoL) in the context of new therapies and updated standard of care guidelines. METHODS: DISCOVER CKD is an observational cohort study enrolling adult patients with CKD, defined by an International Classification of Diseases, 10th Revision code, or with two estimated glomerular filtration rate measures < 75 ml/min/1.73 m2 recorded 91-730 days apart. We describe the demographics, baseline characteristics and patient-reported outcomes of patients enrolled in the prospective phase. RESULTS: Of 1052 patients (mean age 62.5 years; 36.9% female) enrolled from the USA, UK, Spain, Italy, Sweden and Japan, 727 (69.1%) had stage 2-3b CKD and 325 (30.9%) had stage 4-5 CKD. Overall, 72.4%, 43.0% and 37.5% of patients had histories of hypertension, diabetes and hyperlipidaemia, respectively. In total, 58.7% and 14.0% were receiving renin-angiotensin-aldosterone system inhibitors (RAASi) and sodium-glucose co-transporter 2 inhibitors (SGLT2i), respectively. Compared with patients with stage 2-3b CKD, patients with stage 4-5 CKD reported numerically greater symptom burden across all 11 symptoms measured, numerically worse HRQoL across all eight categories measured using the 36-item Short Form (SF-36) questionnaire, and numerically greater impairment at work across all four categories measured using the Work Productivity and Activity Impairment chronic kidney disease (WPAI-CKD) questionnaire. Compared with patients with stage 2-3b CKD, a higher proportion of patients with stage 4-5 CKD had anaemia, hyperkalaemia and oedema (49.8% vs. 16.9%, 21.8% vs. 8.4% and 17.5% vs. 9.5%, respectively). CONCLUSIONS: These contemporary real-world data from six countries highlight the substantial symptom, medication and psychosocial burden associated with CKD, and continued gaps in treatment. Graphical abstract available for this article. TRIAL REGISTRATION: ClinicalTrials.gov identifier, NCT04034992."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/date> "2024-11-29" .
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<https://discovery.ucl.ac.uk/id/org/ext-0edd8791b6b9cdbf07ab4d5a2b318215> <http://xmlns.com/foaf/0.1/name> "Springer Verlag"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/publication/ext-0741238X> <http://xmlns.com/foaf/0.1/name> "Advances in Therapy"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-0741238X> .
<https://discovery.ucl.ac.uk/id/publication/ext-0741238X> <http://www.w3.org/2002/07/owl#sameAs> <urn:issn:0741238X> .
<https://discovery.ucl.ac.uk/id/publication/ext-0741238X> <http://purl.org/ontology/bibo/issn> "0741238X" .
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<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-0aaacc85f6875899dc3b520148eba199> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b1b4a530b0a505e80471d113a4859da6> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
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<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7bf60dddf7ae7c3c0d8f8880c9ee1966> .
<https://discovery.ucl.ac.uk/id/eprint/10204684> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10204684#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10204684#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-7bf60dddf7ae7c3c0d8f8880c9ee1966> .
<https://discovery.ucl.ac.uk/id/person/ext-0aaacc85f6875899dc3b520148eba199> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0aaacc85f6875899dc3b520148eba199> <http://xmlns.com/foaf/0.1/givenName> "Carol"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0aaacc85f6875899dc3b520148eba199> <http://xmlns.com/foaf/0.1/familyName> "Pollock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0aaacc85f6875899dc3b520148eba199> <http://xmlns.com/foaf/0.1/name> "Carol Pollock"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> <http://xmlns.com/foaf/0.1/givenName> "Eiichiro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> <http://xmlns.com/foaf/0.1/familyName> "Kanda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8a5a80ec05d6fbe21263aaa31c31169> <http://xmlns.com/foaf/0.1/name> "Eiichiro Kanda"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> <http://xmlns.com/foaf/0.1/givenName> "Steven"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> <http://xmlns.com/foaf/0.1/familyName> "Fishbane"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a284a8f131c2ee49336d73a6d06a9834> <http://xmlns.com/foaf/0.1/name> "Steven Fishbane"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> <http://xmlns.com/foaf/0.1/givenName> "Richard"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> <http://xmlns.com/foaf/0.1/familyName> "Ofori-Asenso"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9c78ae166180e84eef86f204fca58f9e> <http://xmlns.com/foaf/0.1/name> "Richard Ofori-Asenso"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> <http://xmlns.com/foaf/0.1/givenName> "Surendra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> <http://xmlns.com/foaf/0.1/familyName> "Pentakota"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7ea67730f01fee39da715560620a0509> <http://xmlns.com/foaf/0.1/name> "Surendra Pentakota"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> <http://xmlns.com/foaf/0.1/givenName> "Hungta"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> <http://xmlns.com/foaf/0.1/familyName> "Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a2f9887303d334c02057fc2d71c67522> <http://xmlns.com/foaf/0.1/name> "Hungta Chen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> <http://xmlns.com/foaf/0.1/givenName> "Juan Jose"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> <http://xmlns.com/foaf/0.1/familyName> "Garcia Sanchez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-43b85c8070fb93add466164b3435a867> <http://xmlns.com/foaf/0.1/name> "Juan Jose Garcia Sanchez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> <http://xmlns.com/foaf/0.1/givenName> "Carolyn SP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> <http://xmlns.com/foaf/0.1/familyName> "Lam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-920f863b9fa8de7d7cb057a2a496af11> <http://xmlns.com/foaf/0.1/name> "Carolyn SP Lam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1b4a530b0a505e80471d113a4859da6> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b1b4a530b0a505e80471d113a4859da6> <http://xmlns.com/foaf/0.1/givenName> "Juan-Jesus"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1b4a530b0a505e80471d113a4859da6> <http://xmlns.com/foaf/0.1/familyName> "Carrero"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b1b4a530b0a505e80471d113a4859da6> <http://xmlns.com/foaf/0.1/name> "Juan-Jesus Carrero"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> <http://xmlns.com/foaf/0.1/givenName> "Naoki"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> <http://xmlns.com/foaf/0.1/familyName> "Kashihara"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e714d734114e267e5cfaad4dac8224a8> <http://xmlns.com/foaf/0.1/name> "Naoki Kashihara"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> <http://xmlns.com/foaf/0.1/givenName> "Roberto"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> <http://xmlns.com/foaf/0.1/familyName> "Pecoits-Filho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f7243692ebe105c12d3987057c773cb5> <http://xmlns.com/foaf/0.1/name> "Roberto Pecoits-Filho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7bf60dddf7ae7c3c0d8f8880c9ee1966> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7bf60dddf7ae7c3c0d8f8880c9ee1966> <http://xmlns.com/foaf/0.1/givenName> "David C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7bf60dddf7ae7c3c0d8f8880c9ee1966> <http://xmlns.com/foaf/0.1/familyName> "Wheeler"^^<http://www.w3.org/2001/XMLSchema#string> .
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