eprintid: 10204530 rev_number: 10 eprint_status: archive userid: 699 dir: disk0/10/20/45/30 datestamp: 2025-02-11 11:15:16 lastmod: 2025-02-11 11:16:19 status_changed: 2025-02-11 11:15:16 type: article metadata_visibility: show sword_depositor: 699 creators_name: Rodriguez-Sanchez, Lara creators_name: Cathelineau, Xavier creators_name: De Reijke, Theo M creators_name: Stricker, Phillip creators_name: Emberton, Mark creators_name: Lantz, Anna creators_name: Miñana López, Bernardino creators_name: Dominguez-Escrig, Jose Luis creators_name: Bianco, Fernando J creators_name: Salomon, Georg creators_name: Haider, Aiman creators_name: Mitra, Anita creators_name: Bossi, Alberto creators_name: Compérat, Eva creators_name: Reiter, Robert creators_name: Laguna, Pilar creators_name: Fiard, Gaelle creators_name: Lunelli, Luca creators_name: Schade, George R creators_name: Chiu, Peter Ka-Fung creators_name: Macek, Petr creators_name: Kasivisvanathan, Veeru creators_name: Rosette, Jean JMCH creators_name: Polascik, Thomas J creators_name: Rastinehad, Ardeshir R creators_name: Rodriguez, Alejandro creators_name: Sanchez-Salas, Rafael creators_name: The FALCON group, title: Refining partial gland ablation for localised prostate cancer: the FALCON project ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D16 keywords: Prostate cancer; ablation techniques; Delphi study; consensus; patient selection; energy source selection; treatment evaluation note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Objectives: To provide a contemporary statement on focal therapy (FT) for localised prostate cancer (PCa) from an international and diverse group of physicians treating localised PCa, with the aim of overcoming the limitations of previous consensus statements, which were restricted to early adopters, and to offer direction regarding the various aspects of FT application that are currently not well defined. // Materials and Methods: The FocAL therapy CONsensus (FALCON) project began with a 154-item online survey, developed following a steering committee discussion and literature search. Invitations to participate were extended to a large, diverse group of professionals experienced in PCa management. From 2022 to 2023, a Delphi consensus study consisting of three online rounds was conducted using the Modified Delphi method. A 1–9 Likert scale was used for the survey, which was followed by an in-person expert meeting. The threshold for achieving consensus was set at 70% agreement/disagreement. Six main aspects of FT were covered: (i) patient selection; (ii) energy source selection; (iii) treatment approach; (iv) treatment evaluation and follow-up; (v) treatment cost and accessibility; and (vi) future perspectives. // Results: Of 246 initial participants, 148 (60%) completed all three rounds. Based on participant feedback, 27 new statements were added in the second round, and 33 questions related to personal expertise, for which consensus was not necessary, were excluded. After the third and final round, consensus had not been reached for 69 items. These items were discussed at the in-person meeting, resulting in a consensus of 57 additional items. Consensus was finally not reached on 12 items. Given the volume of data, the voting outcomes are summarised in this article, with a detailed breakdown presented in the form of figures and tables. // Conclusions: The FALCON project delivered a significant consensus on the approach to FT for localised PCa. Additionally, it highlighted gaps in our knowledge that may provide guidance for future research. date: 2025-02-04 date_type: published publisher: Wiley official_url: https://doi.org/10.1111/bju.16669 full_text_type: other language: eng verified: verified_manual elements_id: 2358812 doi: 10.1111/bju.16669 medium: Print-Electronic lyricists_name: Emberton, Mark lyricists_name: Kasivisvanathan, Veerappan lyricists_id: MEMBE52 lyricists_id: VKASI35 actors_name: Kasivisvanathan, Veerappan actors_id: VKASI35 actors_role: owner funding_acknowledgements: [AngioDynamics] full_text_status: restricted publication: BJU International event_location: England issn: 1464-4096 citation: Rodriguez-Sanchez, Lara; Cathelineau, Xavier; De Reijke, Theo M; Stricker, Phillip; Emberton, Mark; Lantz, Anna; Miñana López, Bernardino; ... The FALCON group; + view all <#> Rodriguez-Sanchez, Lara; Cathelineau, Xavier; De Reijke, Theo M; Stricker, Phillip; Emberton, Mark; Lantz, Anna; Miñana López, Bernardino; Dominguez-Escrig, Jose Luis; Bianco, Fernando J; Salomon, Georg; Haider, Aiman; Mitra, Anita; Bossi, Alberto; Compérat, Eva; Reiter, Robert; Laguna, Pilar; Fiard, Gaelle; Lunelli, Luca; Schade, George R; Chiu, Peter Ka-Fung; Macek, Petr; Kasivisvanathan, Veeru; Rosette, Jean JMCH; Polascik, Thomas J; Rastinehad, Ardeshir R; Rodriguez, Alejandro; Sanchez-Salas, Rafael; The FALCON group; - view fewer <#> (2025) Refining partial gland ablation for localised prostate cancer: the FALCON project. BJU International 10.1111/bju.16669 <https://doi.org/10.1111/bju.16669>. (In press). document_url: https://discovery.ucl.ac.uk/id/eprint/10204530/1/Kasivisvanathan_FINAL%20ACCEPTED%20Falcon%20Manuscript.Review2%28without%20tracks%29.BJUI.pdf