eprintid: 10204528
rev_number: 10
eprint_status: archive
userid: 699
dir: disk0/10/20/45/28
datestamp: 2025-02-11 15:24:04
lastmod: 2025-02-11 15:24:04
status_changed: 2025-02-11 15:24:04
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Tampaki, Maria
creators_name: Tsochatzis, Emmanouil
creators_name: Lekakis, Vasileios
creators_name: Cholongitas, Evangelos
title: Prevalence, characteristics and outcomes of patients with metabolic and alcohol related/associated liver disease (MetALD): a systematic review and meta-analysis
ispublished: pub
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G91
keywords: Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, MetALD, Metabolic dysfunction associated steatotic liver, disease, Alcohol related liver disease, Steatotic liver disease, SLD, MASLD, ALD, ALL-CAUSE MORTALITY, CARDIOVASCULAR EVENTS, PUBLICATION BIAS, CONSUMPTION, RISK, IMPACTS
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.

This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Background: In light of the new nomenclature of steatotic liver disease (SLD), we aimed to enhance the existing knowledge on the epidemiology and clinical outcomes of metabolic and alcohol related/associated liver disease (MetALD). Methods: A systematic review and meta-analysis were performed in Medline/PubMed, Embase, Scopus and Cochrane databases to evaluate the prevalence and outcomes of MetALD within the SLD population and to compare the characteristics between MetALD patients and those with metabolic dysfunction associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD). Nineteen studies from nine countries that evaluated 4,543,341 adult participants with SLD were included. Results: The pooled overall prevalence of MetALD among the SLD population was 10 % (95%CI:7–13 %) without significant difference between Asian and non-Asian populations. However, MetALD was more frequent in men than women (86 % vs 14 %, p < 0.01), while Asian MetALD patients, were more frequent men (92 % vs 66 %, p < 0.01) compared to non-Asians. Additionally, in terms of metabolic characteristics there were no significant differences between MetALD, MASLD and ALD patients. Regarding outcomes, patients with MetALD, compared to non-SLD, were at increased risk of all-cause [HR 1.44 (95%CI:1.24–1.66)], cardiovascular disease (CVD) [HR 1.17 (95%CI:1.12–1.21)] and cancer-related mortality [HR 2.07 (95%CI:1.32–3.25)]. Finally, patients with MetALD, had increased incidence of CVD and liver decompensating events, compared to non-SLD participants [HR 1.49 (95%CI:1.03–2.15); HR 10.55 (95%CI:3.46–32.16) respectively]. Conclusions: Based on the existing literature, patients with MetALD consist a significant part of the SLD population, with high all-cause, CVD and cancer-related mortality and increased risk for CVD and hepatic decompensation.
date: 2025-02
date_type: published
publisher: W B SAUNDERS CO-ELSEVIER INC
official_url: https://doi.org/10.1016/j.metabol.2024.156101
full_text_type: other
language: eng
verified: verified_manual
elements_id: 2345031
doi: 10.1016/j.metabol.2024.156101
medium: Print-Electronic
pii: S0026-0495(24)00329-9
lyricists_name: Tsochatzis, Emmanouil
lyricists_id: ETSOC40
actors_name: Tsochatzis, Emmanouil
actors_id: ETSOC40
actors_role: owner
full_text_status: restricted
publication: Metabolism
volume: 163
article_number: 156101
pages: 9
event_location: United States
issn: 0026-0495
citation:        Tampaki, Maria;    Tsochatzis, Emmanouil;    Lekakis, Vasileios;    Cholongitas, Evangelos;      (2025)    Prevalence, characteristics and outcomes of patients with metabolic and alcohol related/associated liver disease (MetALD): a systematic review and meta-analysis.                   Metabolism , 163     , Article 156101.  10.1016/j.metabol.2024.156101 <https://doi.org/10.1016/j.metabol.2024.156101>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10204528/3/Tsochatzis_R2%20MetALD%20send.pdf