TY  - INPR
PB  - American Chemical Society (ACS)
UR  - https://doi.org/10.1021/acs.macromol.4c01621
SN  - 0024-9297
N2  - Molecular recognition is of crucial importance in several healthcare applications, such as sensing, drug delivery, and therapeutics. Molecularly imprinted polymers (MIPs) present an interesting alternative to biological receptors (e.g., antibodies, enzymes) for this purpose since synthetic receptors overcome the limited robustness, flexibility, high-cost, and potential for inhibition that comes with natural recognition elements. However, off the shelf MIP products remain limited, which is likely due to the lack of a scalable production approach that can manufacture these materials in high yields and narrow and defined size distributions to have full control over their properties. In this Perspective, we will confer how breakthroughs in the automation of MIP design, manufacturing, and evaluation of performance will accelerate the (commercial) implementation of MIPs in healthcare technology. In addition, we will discuss how prediction of the in vivo behavior of MIPs with animal-free technologies (e.g., 3D tissue models) will be critical to assess their clinical potential.
ID  - discovery10204297
A1  - Garg, Saweta
A1  - Singla, Pankaj
A1  - Kaur, Sarbjeet
A1  - Canfarotta, Francesco
A1  - Velliou, Eirini
A1  - Dawson, James A
A1  - Kapur, Nikil
A1  - Warren, Nicholas J
A1  - Amarnath, Shoba
A1  - Peeters, Marloes
KW  - Immunology
KW  -  Materials
KW  -  Monomers
KW  -  Peptides And Proteins
KW  -  Polymers
JF  - Macromolecules
AV  - public
Y1  - 2025/02/01/
TI  - Future Perspectives on the Automation and Biocompatibility of Molecularly Imprinted Polymers for Healthcare Applications
N1  - Copyright © 2025 The Authors. Published by American Chemical Society. This publication is licensed under CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/).
ER  -