TY  - INPR
JF  - IEEE Transactions on Biomedical Circuits and Systems
A1  - Habibollahi, Maryam
A1  - Jiang, Dai
A1  - Lancashire, Henry Thomas
A1  - Demosthenous, Andreas
ID  - discovery10204210
N2  - A mm-sized, implantable neural interface for bidirectional control of the peripheral nerves with microchannel electrodes is presented in this paper. The application-specific integrated circuit (ASIC) developed in a 0.18 ?m CMOS technology is designed to achieve highly selective, concurrent control of 300-?m-wide groups of small nerve sections. It has in-situ, high-voltage-compliant (45 V) electrical stimulation and low-voltage (1.8 V) neural recording in each channel. Biphasic stimulus current pulses up to 124 ?A with a 2 ?A resolution are generated between 7.4 Hz and 20 kHz frequencies to stimulate and block neural activity. Action potentials are measured across a 10 kHz bandwidth with a variable gain response that ranges up to 72 dB. The neural recording front-end implements a low-power and low-noise biopotential amplifier with an input-referred noise (IRN) of 2.74 ?Vrms across the full measurement bandwidth. Automatic detection and reduction of stimulus artifacts is realised using a pole-shifting mechanism with a 1-ms amplifier recovery time. Versatile control of concurrently-operating channels is achieved in a two-channel, 2.31 mm2 interface ASIC using local control that allows up to seven devices to operate in parallel. Invitro validation of the active interface shows feasibility for closed-loop peripheral nerve control, while ex-vivo analyses of concurrent stimulation and recording demonstrates the measured neural response to electrical stimuli.
UR  - https://doi.org/10.1109/tbcas.2025.3533612
PB  - Institute of Electrical and Electronics Engineers (IEEE)
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
TI  - An Active Microchannel Neural Interface for Implantable Electrical Stimulation and Recording
EP  - 13
Y1  - 2025/01/27/
AV  - public
SP  - 1
ER  -