%0 Journal Article
%A Habibollahi, Maryam
%A Jiang, Dai
%A Lancashire, Henry Thomas
%A Demosthenous, Andreas
%D 2025
%F discovery:10204210
%I Institute of Electrical and Electronics Engineers (IEEE)
%J IEEE Transactions on Biomedical Circuits and Systems
%P 1-13
%T An Active Microchannel Neural Interface for Implantable Electrical Stimulation and Recording
%U https://discovery.ucl.ac.uk/id/eprint/10204210/
%X A mm-sized, implantable neural interface for bidirectional control of the peripheral nerves with microchannel electrodes is presented in this paper. The application-specific integrated circuit (ASIC) developed in a 0.18 μm CMOS technology is designed to achieve highly selective, concurrent control of 300-μm-wide groups of small nerve sections. It has in-situ, high-voltage-compliant (45 V) electrical stimulation and low-voltage (1.8 V) neural recording in each channel. Biphasic stimulus current pulses up to 124 μA with a 2 μA resolution are generated between 7.4 Hz and 20 kHz frequencies to stimulate and block neural activity. Action potentials are measured across a 10 kHz bandwidth with a variable gain response that ranges up to 72 dB. The neural recording front-end implements a low-power and low-noise biopotential amplifier with an input-referred noise (IRN) of 2.74 μVrms across the full measurement bandwidth. Automatic detection and reduction of stimulus artifacts is realised using a pole-shifting mechanism with a 1-ms amplifier recovery time. Versatile control of concurrently-operating channels is achieved in a two-channel, 2.31 mm2 interface ASIC using local control that allows up to seven devices to operate in parallel. Invitro validation of the active interface shows feasibility for closed-loop peripheral nerve control, while ex-vivo analyses of concurrent stimulation and recording demonstrates the measured neural response to electrical stimuli.
%Z This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.