TY  - JOUR
JF  - Patient Preference and Adherence
N1  - © 2025 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (https://creativecommons.org/licenses/by-nc/3.0/).
TI  - A Systematic Review Uncovering Modifiable Influences on Statin Adherence
N2  - Statins are effective in reducing cardiovascular disease (CVD) risk, but adherence rates remain low globally. Understanding and addressing modifiable influences on adherence is key to improving outcomes. Existing reviews have methodological limitations, often failing to integrate qualitative and quantitative data or consider specific barriers to statin adherence. This systematic review aimed to identify modifiable barriers and facilitators to statin adherence using the Theoretical Domains Framework (TDF). A comprehensive search of Embase, MEDLINE, PsycINFO, and CINAHL was conducted, covering studies from January 1998 to November 2023. Data were coded to TDF domains and synthesized to identify specific influences on adherence. The nature of the evidence (qualitative or quantitative) was recorded for each influence, and variations among patient groups were noted. Seventy studies from 20 countries were included, with only one focused on ethnic minorities. The most commonly identified domains affecting adherence were ?Beliefs about Consequences?, ?Knowledge?, ?Environmental Context and Resources?, and ?Social Influences?. Key factors included knowledge of disease, perceived disease threat, perceived benefits of statins, and patient-provider communication and trust. While side effects had inconsistent associations with adherence, forgetfulness was mainly addressed in quantitative studies, and social influences were highlighted in qualitative research. This review identified modifiable factors that could improve statin adherence. Future research should focus on addressing barriers faced by underrepresented groups to create more inclusive and effective interventions that enhance patient support and communication for better health outcomes.
PB  - Informa UK Limited
UR  - https://doi.org/10.2147/ppa.s502645
Y1  - 2025///
EP  - 48
KW  - medication adherence
KW  -  psychological determinants
KW  -  dyslipidaemia
KW  -  theoretical domains framework
A1  - Rosenberg, Javiera
A1  - Lampridou, Smaragda
A1  - Moores, Amelia
A1  - Garfield, Sara
A1  - Wingfield, David
A1  - Judah, Gaby
SP  - 29
AV  - public
VL  - 19
ID  - discovery10204168
ER  -