TY  - INPR
UR  - https://doi.org/10.1002/marc.202400744
PB  - WILEY-V C H VERLAG GMBH
SN  - 1022-1336
N2  - Antimicrobial resistance poses a growing threat to public health globally. Multidrug resistant Pseudomonas (P.) aeruginosa is detected in many infected wounds and is very challenging to treat with antibiotics. An alternative to antibiotics is to use bacteriophages, highly specific viruses able to kill even resistant bacteria. This work incorporates anti-P. aeruginosa Neko phages into monoaxial and coaxial electrospun fibers to explore their potential for treating infected wounds. Phages are blended with polyvinyl alcohol (PVA) solution and either processed directly into fibers or used as the core in coaxial electrospinning with polyvinylpyrrolidone (PVP) and PVP/ethyl cellulose (EC) shell solutions. Coaxial fibers stored at ?20 °C show promising stability results, with negligible phage titer loss after 6 months of storage. Phage release can be controlled by varying the shell composition. Coaxial fibers with PVP as the shell (PVA/Su PVP + phage) demonstrate immediate release while fibers with PVP/EC as the shell (PVA/Su PVP/EC + phage) display extended-release. The antibacterial efficacy of phage lysate and phage-loaded fibers is studied by isothermal calorimetry and found to be unaffected by electrospinning. Thus, it appears that phage-loaded electrospun fibers merit further investigation as potential wound dressing materials.
ID  - discovery10204097
A1  - Ju, Tian
A1  - Li, Jixuan
A1  - Weston, Andrew
A1  - Satta, Giovanni
A1  - Bolognini, Sara
A1  - Di Luca, Mariagrazia
A1  - Gaisford, Simon
A1  - Williams, Gareth R
KW  - Bacteriophage
KW  -  coaxial electrospinning
KW  -  ethyl cellulose (EC)
KW  -  isothermal
calorimetry
KW  -  polyvinyl alcohol (PVA)
KW  -  polyvinylpyrrolidone (PVP)
KW  -  pseudomonas aeruginosa
JF  - Macromolecular Rapid Communications
AV  - public
Y1  - 2025/01/13/
EP  - 14
TI  - Anti-Pseudomonas Aeruginosa Bacteriophage Loaded Electrospun Fibers for Antibacterial Wound Dressings
N1  - Copyright © 2025 The Author(s). Macromolecular Rapid Communications published by Wiley-VCH GmbH
This is an open access article under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
ER  -