TY  - JOUR
EP  - 1682
N2  - Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non?sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.
UR  - https://doi.org/10.1038/nn.3253
VL  - 15
A1  - Barrios, Arantza
A1  - Ghosh, Rajarshi
A1  - Fang, Chunhui
A1  - Emmons, Scott W
A1  - Barr, Maureen M
ID  - discovery10204053
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
PB  - NATURE PUBLISHING GROUP
Y1  - 2012/12//
TI  - PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans
JF  - Nature Neuroscience
AV  - public
IS  - 12
SP  - 1675
SN  - 1097-6256
ER  -