<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/eprint/10204033> <http://purl.org/dc/terms/title> "Factor VIII Antibodies Demonstrate Type I or Type II Kinetics in Acquired Haemophilia A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10204033> <http://purl.org/ontology/bibo/abstract> "Background:\r\nAcquired haemophilia A (AHA) is an acquired bleeding disorder resulting from autoantibodies against Factor VIII (FVIII). Previous studies have reported differences in FVIII inhibitor kinetics (type I or type II) in AHA compared to severe haemophilia A.//\r\n\r\nAim:\r\nTo characterise inhibitor kinetics in AHA and evaluate the proportions displaying type I, II or indeterminate kinetics. //\r\n\r\nMethods:\r\nSingle-centre retrospective study of inhibitor kinetics in adults with AHA. Type I kinetics were defined as linear FVIII inhibition with ≥ 97% FVIII inactivation. Type II kinetics were defined as non-linear kinetics and inability to completely neutralise FVIII. Inhibitor titres were calculated using two methods outlined by the International Council for Standardisation in Haematology.//\r\n\r\nResults:\r\nBaseline samples from 34 patients were included. Fifteen samples (44.1%) exhibited type I kinetics, 16 samples (47.1%) exhibited type II kinetics and 3 (8.8%) were indeterminate. Plateau mean residual FVIII:C was higher for inhibitors displaying type II compared to type I kinetics (18.6 vs. 2.9 IU/dL, p < 0.0001). Non-linear regression using a dose-response curve without categorisation for kinetics type yielded a poor fit (R2 = 38%), which improved with refitting using categories of type I or II kinetics that explained 87% and 85% of the variability. The median difference in inhibitor titre between the two reporting methods was 5% and 15% in the type I and II kinetics groups, respectively.//\r\n\r\nConclusion:\r\nFVIII autoantibodies demonstrate either type I or type II kinetics. Greater discrepancy in reported inhibitor titres depending on the method used is seen for inhibitors with type II kinetics."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10204033> <http://purl.org/dc/terms/date> "2025-01-15" .
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<https://discovery.ucl.ac.uk/id/person/ext-0e256ef86dd6e85f04c187ede35284a0> <http://xmlns.com/foaf/0.1/givenName> "Kirollos"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0e256ef86dd6e85f04c187ede35284a0> <http://xmlns.com/foaf/0.1/familyName> "Kamel"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0e256ef86dd6e85f04c187ede35284a0> <http://xmlns.com/foaf/0.1/name> "Kirollos Kamel"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-e9f956c01e72c2a294f95cb7057215a3> <http://xmlns.com/foaf/0.1/givenName> "Anne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9f956c01e72c2a294f95cb7057215a3> <http://xmlns.com/foaf/0.1/familyName> "Riddell"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9f956c01e72c2a294f95cb7057215a3> <http://xmlns.com/foaf/0.1/name> "Anne Riddell"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-b263b7a2de5d042d95456dda803f9918> <http://xmlns.com/foaf/0.1/name> "Paul Batty"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-eeb7f6d382b6ec83277426227b15dab0> <http://xmlns.com/foaf/0.1/givenName> "Pratima"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eeb7f6d382b6ec83277426227b15dab0> <http://xmlns.com/foaf/0.1/familyName> "Chowdary"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eeb7f6d382b6ec83277426227b15dab0> <http://xmlns.com/foaf/0.1/name> "Pratima Chowdary"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/person/ext-de5474eb78bd47b49dd9b154fcd2d662> <http://xmlns.com/foaf/0.1/givenName> "Sofia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de5474eb78bd47b49dd9b154fcd2d662> <http://xmlns.com/foaf/0.1/familyName> "Sardo Infirri"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-de5474eb78bd47b49dd9b154fcd2d662> <http://xmlns.com/foaf/0.1/name> "Sofia Sardo Infirri"^^<http://www.w3.org/2001/XMLSchema#string> .
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<https://discovery.ucl.ac.uk/id/document/1822064> <http://www.w3.org/2000/01/rdf-schema#label> "Factor VIII Antibodies Demonstrate Type I or Type II Kinetics in Acquired Haemophilia A (PDF)"^^<http://www.w3.org/2001/XMLSchema#string> .
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