TY  - JOUR
SN  - 1932-7447
UR  - https://doi.org/10.1021/acs.jpcc.4c06381
JF  - The Journal of Physical Chemistry C
A1  - Skinner, William H
A1  - Salimi, Marzieh
A1  - Moran, Laura
A1  - Blein-Dezayes, Ioana
A1  - Mehta, Megha
A1  - Mosca, Sara
A1  - Vaideanu, Alexandra-Geanina
A1  - Gardner, Benjamin
A1  - Palombo, Francesca
A1  - Schatzlein, Andreas G
A1  - Matousek, Pavel
A1  - Harries, Tim
A1  - Stone, Nick
VL  - 129
SP  - 1864
N1  - Copyright © 2025 The Authors. Published by American Chemical Society. This publication is licensed under 
CC-BY 4.0 .
IS  - 3
ID  - discovery10203934
N2  - Many different types of nanoparticles have been developed for photothermal therapy (PTT), but directly comparing their efficacy as heaters and determining how they will perform when localized at depth in tissue remains complex. To choose the optimal nanoparticle for a desired hyperthermic therapy, it is vital to understand how efficiently different nanoparticles extinguish laser light and convert that energy to heat. In this paper, we apply photothermal mass conversion efficiency (?m) as a metric to compare nanoparticles of different shapes, sizes, and conversion efficiencies. We selected silica-gold nanoshells (AuNShells), gold nanorods (AuNRs), and gold nanostars (AuNStars) as three archetypal nanoparticles for PTT and measured the ?m of each to demonstrate the importance of considering both photothermal efficiency and extinction cross section when comparing nanoparticles. By utilizing a Monte Carlo model, we further applied ?m to model how AuNRs performed when located at tissue depths of 0?30 mm by simulating the depth penetration of near-infrared (NIR) laser light. These results show how nanoparticle concentration, laser power, and tissue depth influence the ramp time to a hyperthermic temperature of 43 °C. The methodology outlined in this paper creates a framework to benchmark the heating efficacy of different nanoparticle types and a means of estimating the feasibility of nanoparticle-mediated PTT at depth in the NIR window. These are key considerations when predicting the potential clinical impact in the early stages of nanoparticle design.
PB  - AMER CHEMICAL SOC
KW  - Science & Technology
KW  -  Physical Sciences
KW  -  Technology
KW  -  Chemistry
KW  -  Physical
KW  -  Nanoscience & Nanotechnology
KW  -  Materials Science
KW  -  Multidisciplinary
KW  -  Chemistry
KW  -  Science & Technology - Other Topics
KW  -  Materials Science
KW  -  ABLATION
KW  -  NANORODS
KW  -  SCATTERING
KW  -  NANOCAGES
KW  -  TUMORS
KW  -  CELL
TI  - Plasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues
EP  - 1872
AV  - public
Y1  - 2025/01/09/
ER  -