eprintid: 10203927 rev_number: 10 eprint_status: archive userid: 699 dir: disk0/10/20/39/27 datestamp: 2025-01-24 11:47:20 lastmod: 2025-01-24 11:47:20 status_changed: 2025-01-24 11:47:20 type: article metadata_visibility: show sword_depositor: 699 creators_name: Roth, Eliane creators_name: Bruni, Cosimo creators_name: Petelytska, Liubov creators_name: Becker, Mike Oliver creators_name: Dobrota, Rucsandra creators_name: Jordan, Suzana creators_name: Mihai, Carina creators_name: Muraru, Sinziana creators_name: Carreira, Patricia E creators_name: De Vries-Bouwstra, Jeska creators_name: Braun-Moscovici, Yolanda creators_name: Liakouli, Vasiliki creators_name: Moroncini, Gianluca creators_name: Bergmann, Christina creators_name: Mouthon, Luc creators_name: Denton, Christopher P creators_name: De Santis, Maria creators_name: Cauli, Alberto creators_name: Adler, Sabine creators_name: Bernardino, Vera creators_name: Truchetet, Marie-Elise creators_name: Vonk, Madelon creators_name: Del Galdo, Francesco creators_name: Hoffmann-Vold, Anna-Maria creators_name: Distler, Oliver creators_name: Elhai, Muriel creators_name: EUSTAR collaborators, title: Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort ispublished: inpress divisions: UCL divisions: B02 divisions: C10 divisions: D17 divisions: G90 keywords: gastroesophageal reflux disease, interstitial lung disease, progression, systemic sclerosis note: Copyright © The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: OBJECTIVES: Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD. METHODS: SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ≥10% or relative FVC decline between 5-9% in association with relative DLCO decline of ≥ 15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression. RESULTS: 5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p < 0.001) and more severe lung involvement with lower FVC (85.8±22.1 vs 90.2±20.1, p < 0.001), lower DLCO (60.8±19.7 vs 65.3±20.6, p < 0.001) and worse performance at the 6-minute walking test. Female sex (HR: 1.39 [1.07-1.80], p = 0.012) and older age (HR: 1.02 [1.01-1.03], p < 0.001) independently predicted ILD progression in SSc-ILD patients with GERD. CONCLUSION: SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered as risk factor for ILD progression. date: 2025-01-08 date_type: published publisher: Oxford University Press (OUP) official_url: https://doi.org/10.1093/rheumatology/keaf016 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 2354649 doi: 10.1093/rheumatology/keaf016 medium: Print-Electronic pii: 7945677 lyricists_name: Denton, Christopher lyricists_id: CPDEN87 actors_name: Denton, Christopher actors_id: CPDEN87 actors_role: owner full_text_status: public publication: Rheumatology event_location: England issn: 1462-0324 citation: Roth, Eliane; Bruni, Cosimo; Petelytska, Liubov; Becker, Mike Oliver; Dobrota, Rucsandra; Jordan, Suzana; Mihai, Carina; ... EUSTAR collaborators; + view all <#> Roth, Eliane; Bruni, Cosimo; Petelytska, Liubov; Becker, Mike Oliver; Dobrota, Rucsandra; Jordan, Suzana; Mihai, Carina; Muraru, Sinziana; Carreira, Patricia E; De Vries-Bouwstra, Jeska; Braun-Moscovici, Yolanda; Liakouli, Vasiliki; Moroncini, Gianluca; Bergmann, Christina; Mouthon, Luc; Denton, Christopher P; De Santis, Maria; Cauli, Alberto; Adler, Sabine; Bernardino, Vera; Truchetet, Marie-Elise; Vonk, Madelon; Del Galdo, Francesco; Hoffmann-Vold, Anna-Maria; Distler, Oliver; Elhai, Muriel; EUSTAR collaborators; - view fewer <#> (2025) Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort. Rheumatology 10.1093/rheumatology/keaf016 <https://doi.org/10.1093/rheumatology%2Fkeaf016>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10203927/7/Denton_keaf016.pdf