TY  - INPR
Y1  - 2025/01/08/
AV  - public
TI  - Gastroesophageal reflux disease is associated with a more severe interstitial lung disease in systemic sclerosis in the EUSTAR cohort
N1  - Copyright © The Author(s) 2025. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
SN  - 1462-0324
PB  - Oxford University Press (OUP)
UR  - https://doi.org/10.1093/rheumatology/keaf016
ID  - discovery10203927
N2  - OBJECTIVES: Gastroesophageal reflux disease (GERD) is frequent in systemic sclerosis (SSc) and could predict progression of interstitial lung disease (ILD). We aimed to analyse (1) the prevalence of GERD among SSc-ILD patients, (2) its association with disease characteristics and (3) predictive factors for ILD progression in SSc-ILD patients with GERD. METHODS: SSc patients from the EUSTAR database with ILD were included. GERD was labeled as present if reflux/dysphagia was reported at the baseline visit or before. Disease characteristics of patients with and without GERD were compared at baseline. ILD progression was defined as relative FVC decline ?10% or relative FVC decline between 5-9% in association with relative DLCO decline of???15% over 12±3 months of follow-up. Prognostic factors for ILD progression, overall survival and progression-free survival in SSc-ILD patients with GERD were tested by multivariable Cox regression. RESULTS: 5462 SSc-ILD patients were included, 4400 (80.6%) had GERD. Patients with GERD presented more frequently with diffuse cutaneous SSc (OR: 1.44 [1.22-1.69], p?<?0.001) and more severe lung involvement with lower FVC (85.8±22.1 vs 90.2±20.1, p?<?0.001), lower DLCO (60.8±19.7 vs 65.3±20.6, p?<?0.001) and worse performance at the 6-minute walking test. Female sex (HR: 1.39 [1.07-1.80], p?=?0.012) and older age (HR: 1.02 [1.01-1.03], p?<?0.001) independently predicted ILD progression in SSc-ILD patients with GERD. CONCLUSION: SSc-ILD patients with GERD appear to suffer from a more severe SSc disease. In this population, female sex may be considered as risk factor for ILD progression.
KW  - gastroesophageal reflux disease
KW  -  interstitial lung disease
KW  -  progression
KW  -  systemic sclerosis
A1  - Roth, Eliane
A1  - Bruni, Cosimo
A1  - Petelytska, Liubov
A1  - Becker, Mike Oliver
A1  - Dobrota, Rucsandra
A1  - Jordan, Suzana
A1  - Mihai, Carina
A1  - Muraru, Sinziana
A1  - Carreira, Patricia E
A1  - De Vries-Bouwstra, Jeska
A1  - Braun-Moscovici, Yolanda
A1  - Liakouli, Vasiliki
A1  - Moroncini, Gianluca
A1  - Bergmann, Christina
A1  - Mouthon, Luc
A1  - Denton, Christopher P
A1  - De Santis, Maria
A1  - Cauli, Alberto
A1  - Adler, Sabine
A1  - Bernardino, Vera
A1  - Truchetet, Marie-Elise
A1  - Vonk, Madelon
A1  - Del Galdo, Francesco
A1  - Hoffmann-Vold, Anna-Maria
A1  - Distler, Oliver
A1  - Elhai, Muriel
A1  - EUSTAR collaborators
JF  - Rheumatology
ER  -