eprintid: 10203916
rev_number: 7
eprint_status: archive
userid: 699
dir: disk0/10/20/39/16
datestamp: 2025-01-24 09:03:48
lastmod: 2025-01-24 09:03:48
status_changed: 2025-01-24 09:03:48
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: Bogdanski, AM
creators_name: Acedo, P
creators_name: Wallace, MB
creators_name: van Leerdam, ME
creators_name: Klatte, DCF
title: Recommendations, evidence and sustainability of screening for pancreatic cancer in high-risk individuals
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: G91
keywords: Pancreatic cancer,
Early detection,
Screening,
Surveillance,
High-risk individuals
note: Under a Creative Commons license https://creativecommons.org/licenses/by/4.0/
abstract: Pancreatic cancer is a highly lethal malignancy and is predicted to become the second leading cause of cancer-related deaths by 2030. Early detection significantly improves outcomes, but general population screening remains infeasible due to the low prevalence of the disease and lack of specific biomarkers. This review evaluates current recommendations for pancreatic cancer surveillance in high-risk individuals, synthesises evidence from recent studies and explores the sustainability of current imaging-based surveillance programmes. Challenges such as overdiagnosis, economic feasibility and disparities in access highlight the need for targeted, cost-effective strategies. Collaborative initiatives and consortia are needed to advance biomarker research and refine risk stratification. By integrating evidence-based recommendations with sustainable approaches, this review outlines pathways to improve early detection and reduce mortality from pancreatic cancer.
date: 2025-01-01
date_type: published
publisher: Elsevier BV
official_url: https://doi.org/10.1016/j.bpg.2025.101974
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2354237
doi: 10.1016/j.bpg.2025.101974
lyricists_name: Acedo Nunez, Maria Del Pilar
lyricists_id: PACED64
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Best Practice and Research: Clinical Gastroenterology
article_number: 101974
issn: 1521-6918
citation:        Bogdanski, AM;    Acedo, P;    Wallace, MB;    van Leerdam, ME;    Klatte, DCF;      (2025)    Recommendations, evidence and sustainability of screening for pancreatic cancer in high-risk individuals.                   Best Practice and Research: Clinical Gastroenterology      , Article 101974.  10.1016/j.bpg.2025.101974 <https://doi.org/10.1016/j.bpg.2025.101974>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10203916/1/1-s2.0-S1521691825000010-main.pdf