TY  - INPR
TI  - Recommendations, evidence and sustainability of screening for pancreatic cancer in high-risk individuals
AV  - public
Y1  - 2025/01/01/
N1  - Under a Creative Commons license https://creativecommons.org/licenses/by/4.0/
ID  - discovery10203916
N2  - Pancreatic cancer is a highly lethal malignancy and is predicted to become the second leading cause of cancer-related deaths by 2030. Early detection significantly improves outcomes, but general population screening remains infeasible due to the low prevalence of the disease and lack of specific biomarkers. This review evaluates current recommendations for pancreatic cancer surveillance in high-risk individuals, synthesises evidence from recent studies and explores the sustainability of current imaging-based surveillance programmes. Challenges such as overdiagnosis, economic feasibility and disparities in access highlight the need for targeted, cost-effective strategies. Collaborative initiatives and consortia are needed to advance biomarker research and refine risk stratification. By integrating evidence-based recommendations with sustainable approaches, this review outlines pathways to improve early detection and reduce mortality from pancreatic cancer.
SN  - 1521-6918
PB  - Elsevier BV
UR  - https://doi.org/10.1016/j.bpg.2025.101974
JF  - Best Practice and Research: Clinical Gastroenterology
KW  - Pancreatic cancer
KW  - 
Early detection
KW  - 
Screening
KW  - 
Surveillance
KW  - 
High-risk individuals
A1  - Bogdanski, AM
A1  - Acedo, P
A1  - Wallace, MB
A1  - van Leerdam, ME
A1  - Klatte, DCF
ER  -