@article{discovery10203774,
           pages = {2210--2219},
          volume = {54},
            note = {This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.},
       publisher = {SPRINGER},
            year = {2024},
           title = {Quantified small bowel motility assessment on magnetic resonance enterography in paediatric inflammatory bowel disease - does it reflect clinical response?},
         journal = {Pediatric Radiology},
           month = {December},
            issn = {0301-0449},
          author = {Meshaka, R and Fitzke, HE and Barber, J and Jones, K and Taylor, SA and Watson, TA},
        abstract = {Background: Quantified small bowel motility assessment using cine magnetic resonance enterography (MRE) has shown promise as a biomarker in adult inflammatory bowel disease. Whether quantified motility corresponds to treatment response in paediatric inflammatory bowel disease is unknown. Objective: To test whether changes in motility reflect response. Materials and methods: Local ethics approval was granted for this single-institution, retrospective study. All children {\ensuremath{<}} 18�years with confirmed inflammatory bowel disease, who had more than one MRE between Jan 2011-Jan 2022, were included. Simplified MaRIA (sMaRIA) and motility index (quantified motility) at all terminal ileum and diseased non-terminal ileum segments were independently assessed by two radiologists each with {$\ge$} 9�years' experience. Change in ({\ensuremath{\Delta}}) motility index was compared to clinical (gastroenterologist physician's global assessment) and consensus radiological reference standard (response = decrease in sMaRIA of more than or equal to 2 points) in responders versus non-responders using the Mann-Whitney test. Sensitivity and specificity of {\ensuremath{\Delta}} motility index more than zero were compared to decrease in sMaRIA of 2 or more points for identifying clinical response. Results: Of 64 children aged 5-16, 21 out of 64 (33\%) were responders, 37 out of 64 (58\%) were non-responders and 6 out of 64 (9\%) had inactive disease according to clinical reference standard. {\ensuremath{\Delta}} Motility index by both radiologists was higher in responders (+ 16, + 39) than non-responders (-43, -44), P = 0.04, P = 0.01 each radiologist, respectively. Motility index was more sensitive (57\% versus 24\%), but less specific (67\% versus 93\%) than sMaRIA in identifying clinical response. Conclusion: Motility index on cine MRE corresponds to clinical response, and is more sensitive at detecting response compared to sMaRIA in paediatric inflammatory bowel disease. Graphical Abstract: (Figure presented.)},
             url = {https://doi.org/10.1007/s00247-024-06097-y}
}