?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Comparative+Evaluation+of+Zonal+Fibrosis+Patterns+in+Pediatric+and+Adult+Metabolic+Dysfunction-associated+Steatohepatitis+Biopsies+Using+Second+Harmonic+Generation%2Ftwo+Photon+Excitation-based+qFibrosis+Analysis&rft.creator=Alkhouri%2C+Naim&rft.creator=Akbary%2C+Kutbuddin&rft.creator=Ren%2C+Yayun&rft.creator=Naoumov%2C+Nikolai&rft.creator=Chng%2C+Elaine&rft.creator=Tai%2C+Dean&rft.creator=Brees%2C+Dominique&rft.description=Background%3A+Metabolic+dysfunction-associated+steatotic+liver+disease+(MASLD)+is+prevalent+among+children%2C+constituting+the+most+common+chronic+liver+ailment.+Prior+studies+of+liver+biopsies+from+pre-adolescent+children+with+metabolic+dysfunction-associated+steatohepatitis+(MASH)+identified+an+alternate+pattern+characterized+by+zone+1+centered+steatosis%2C+inflammation%2C+and+fibrosis%2C+usually+without+ballooning%2C+which+may+progress+to+advanced+fibrosis.+The+aim+of+this+study+was+to+evaluate+pediatric+MASH+biopsies+using+Second+Harmonic+Generation+(SHG)%2FTwo-Photon+Excitation+(TPE)+microscopy+and+Artificial+Intelligence+(AI)+analysis+and+compare+the+fibrosis+patterns+and+distribution+with+biopsies+from+adults+with+MASH.+%2F%2F%0D%0A%0D%0AMethods%3A+Nine+unstained+biopsies+from+children+(aged+8+to+16+years)+with+MASH+underwent+SHG%2FTPE+and+AI+analysis%2C+yielding+qFibrosis+continuous+values+categorized+into+qFibrosis+stages%2C+based+on+pre-defined+cut-offs.+Biopsies+were+segregated+into+early+(qF0%2FqF1%2FqF2%3B+n%3D3)+and+advanced+(qF3%2FqF4%3B+n%3D6)+fibrosis+groups.+Comparative+analysis+involved+an+adult+cohort+from+a+MASH+clinical+trial+(NCT02855164)%2C+similarly+categorized+into+early+(n%3D96)+and+advanced+(n%3D60)+fibrosis+stages.+Fibrosis+distribution+in+both+cohorts+was+plotted+on+radar+maps+illustrating+portal%3B+periportal%3B+perisinusoidal+(zone+2)%2C+pericentral+and+central+vein+fibrosis%2C+with+zonal+differences+statistically+significant+at+p%E2%89%A40.05+by+Spearman+test.+%2F%2F%0D%0A%0D%0AResults%3A+In+the+early+fibrosis+groups%2C+pediatric+biopsies+exhibited+significantly+greater+perisinusoidal+(PS)+(p%3D0.03)+and+more+portal+fibrosis+compared+to+adults.+In+advanced+fibrosis+groups%2C+pediatric+biopsies+demonstrated+significantly+less+portal+fibrosis+(p%3D0.02)+along+with+markedly+increased+PS+fibrosis+(p%3D0.01)+compared+to+adult+biopsies.+Additionally%2C+pediatric+biopsies+in+advanced+fibrosis+group+had+more+fibrosis+in+periportal+(PP)+and+pericentral+(PC)+regions+compared+to+adult+biopsies.+%2F%2F%0D%0AConclusion%3A+This+quantitative+digital+evaluation+of+MASH+fibrosis+highlights+significant+differences+in+zonal+fibrosis+distribution+in+pediatric+MASH+biopsies+compared+to+adults.+During+the+early+fibrosis+stage%2C+pediatric+biopsies+show+increased+perisinusoidal+and+portal+fibrosis+in+contrast+to+their+adult+counterparts.+At+advanced+stages%2C+there+is+significantly+less+portal+fibrosis+in+pediatric+biopsies+compared+to+adults%2C+although+perisinusoidal+fibrosis+remains+significantly+greater+in+the+pediatric+group.+The+observed+differences+in+fibrosis+patterns+hold+potential+implications+for+accurate+assessment+of+fibrosis+regression+in+pediatric+MASH+clinical+trials.&rft.publisher=LIPPINCOTT+WILLIAMS+%26+WILKINS&rft.date=2024-10&rft.type=Poster&rft.language=eng&rft.source=+++Presented+at%3A+AASLD+The+Liver+Meeting%2C+San+Diego%2C+California%2C+USA.+(2024)+++++&rft.format=text&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10203683%2F1%2FAASLD2024_Pediatric%2520vs%2520Adult%2520NASH_comparison%2520Alkhouri.pdf&rft.identifier=https%3A%2F%2Fdiscovery.ucl.ac.uk%2Fid%2Feprint%2F10203683%2F&rft.rights=open