TY  - JOUR
Y1  - 2025/01/10/
AV  - public
VL  - 13
TI  - The NeuroML ecosystem for standardized multi-scale modeling in neuroscience
N1  - © Copyright Sinha, Gleeson et al. This article is distributed under the terms of the Creative
Commons Attribution License, which permits unrestricted use
and redistribution provided that the original author and source are credited.
UR  - https://doi.org/10.7554/elife.95135.3
PB  - eLife Sciences Publications, Ltd
SN  - 2050-084X
N2  - Data-driven models of neurons and circuits are important for understanding how the properties of membrane conductances, synapses, dendrites, and the anatomical connectivity between neurons generate the complex dynamical behaviors of brain circuits in health and disease. However, the inherent complexity of these biological processes makes the construction and reuse of biologically detailed models challenging. A wide range of tools have been developed to aid their construction and simulation, but differences in design and internal representation act as technical barriers to those who wish to use data-driven models in their research workflows. NeuroML, a model description language for computational neuroscience, was developed to address this fragmentation in modeling tools. Since its inception, NeuroML has evolved into a mature community standard that encompasses a wide range of model types and approaches in computational neuroscience. It has enabled the development of a large ecosystem of interoperable open-source software tools for the creation, visualization, validation, and simulation of data-driven models. Here, we describe how the NeuroML ecosystem can be incorporated into research workflows to simplify the construction, testing, and analysis of standardized models of neural systems, and supports the FAIR (Findability, Accessibility, Interoperability, and Reusability) principles, thus promoting open, transparent and reproducible science.
ID  - discovery10203596
A1  - Sinha, Ankur
A1  - Gleeson, Padraig
A1  - Marin, Bóris
A1  - Dura-Bernal, Salvador
A1  - Panagiotou, Sotirios
A1  - Crook, Sharon
A1  - Cantarelli, Matteo
A1  - Cannon, Robert C
A1  - Davison, Andrew P
A1  - Gurnani, Harsha
A1  - Silver, Robin Angus
JF  - eLife
ER  -