TY  - JOUR
AV  - public
Y1  - 2025/01//
EP  - 15
TI  - Advances in colon-targeted drug technologies
PB  - LIPPINCOTT WILLIAMS & WILKINS
N2  - PURPOSE OF REVIEW: 
Herein, we present an overview of innovative oral technologies utilized in colonic drug delivery systems
that have made significant translational and clinical advancements to treat inflammatory bowel disease
(IBD) in recent years.

RECENT FINDINGS: 
The colon is home to distinct physiological conditions, such as pH and microbiota, that have been
exploited in the development of colonic drug delivery systems for the treatment of local and systemic
diseases. However, given the intra and interindividual variability in the gastrointestinal tract of both healthy
and diseased states, various systems have shown inconsistencies in targeted drug release to the colon.
Recent breakthroughs have led to systems that incorporate multiple independent trigger mechanisms,
ensuring drug release even if one mechanism fails due to physiological variability. Such advanced
platforms have bolstered the development of oral biologics delivery, an especially promising direction
given the lack of commercially available oral antibody medications for IBD. These concepts can be further
enhanced by employing 3D printing which enables the personalisation of medicines.

SUMMARY: 
Leveraging these novel technologies can accurately deliver therapeutics to the colon, allowing for
treatments beyond gastrointestinal tract diseases. To realize the full potential of colonic drug delivery, it is
paramount that research focuses on the clinical translatability and scalability of novel concepts.
ID  - discovery10203576
KW  - Artificial intelligence and machine learning
KW  -  colonic targeting
KW  -  gastro-resistant film coatings
KW  -  mesalamine
formulations
KW  -  oral drug delivery systems and the large intestine
SP  - 9
VL  - 41
IS  - 1
N1  - This is an open access article distributed under the Creative Commons
Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
UR  - https://doi.org/10.1097/mog.0000000000001064
SN  - 0267-1379
A1  - Yeung, Charlotte
A1  - Mccoubrey, Laura E
A1  - Basit, Abdul W
JF  - Current Opinion in Gastroenterology
ER  -