<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10203576> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/dc/terms/title> "Advances in colon-targeted drug technologies"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/ontology/bibo/abstract> "PURPOSE OF REVIEW: \r\nHerein, we present an overview of innovative oral technologies utilized in colonic drug delivery systems\r\nthat have made significant translational and clinical advancements to treat inflammatory bowel disease\r\n(IBD) in recent years.\r\n\r\nRECENT FINDINGS: \r\nThe colon is home to distinct physiological conditions, such as pH and microbiota, that have been\r\nexploited in the development of colonic drug delivery systems for the treatment of local and systemic\r\ndiseases. However, given the intra and interindividual variability in the gastrointestinal tract of both healthy\r\nand diseased states, various systems have shown inconsistencies in targeted drug release to the colon.\r\nRecent breakthroughs have led to systems that incorporate multiple independent trigger mechanisms,\r\nensuring drug release even if one mechanism fails due to physiological variability. Such advanced\r\nplatforms have bolstered the development of oral biologics delivery, an especially promising direction\r\ngiven the lack of commercially available oral antibody medications for IBD. These concepts can be further\r\nenhanced by employing 3D printing which enables the personalisation of medicines.\r\n\r\nSUMMARY: \r\nLeveraging these novel technologies can accurately deliver therapeutics to the colon, allowing for\r\ntreatments beyond gastrointestinal tract diseases. To realize the full potential of colonic drug delivery, it is\r\nparamount that research focuses on the clinical translatability and scalability of novel concepts."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/dc/terms/date> "2025-01" . <https://discovery.ucl.ac.uk/id/document/1818709> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/ontology/bibo/volume> "41" . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/ontology/bibo/issue> "1" . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-25b9d387f8cce0b1154d4f2623450067> <http://xmlns.com/foaf/0.1/name> "LIPPINCOTT WILLIAMS & WILKINS"^^<http://www.w3.org/2001/XMLSchema#string> . 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"Mccoubrey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-1d7f7a7b1b89be432442f0b3248a2506> <http://xmlns.com/foaf/0.1/name> "Laura E Mccoubrey"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9c9f68b812c794133a1c7a98af040b65> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9c9f68b812c794133a1c7a98af040b65> <http://xmlns.com/foaf/0.1/givenName> "Charlotte"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9c9f68b812c794133a1c7a98af040b65> <http://xmlns.com/foaf/0.1/familyName> "Yeung"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9c9f68b812c794133a1c7a98af040b65> <http://xmlns.com/foaf/0.1/name> "Charlotte Yeung"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6d8456c1cdc9148a1e7121bb28c80285> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6d8456c1cdc9148a1e7121bb28c80285> <http://xmlns.com/foaf/0.1/givenName> "Abdul W"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6d8456c1cdc9148a1e7121bb28c80285> <http://xmlns.com/foaf/0.1/familyName> "Basit"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6d8456c1cdc9148a1e7121bb28c80285> <http://xmlns.com/foaf/0.1/name> "Abdul W Basit"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/document/1818709> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1818709> <http://www.w3.org/2000/01/rdf-schema#label> "Advances in colon-targeted drug technologies (Text)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/document/1818709> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10203576/1/Advances%20in%20colon-targeted%20drug%20technologies.pdf> . <https://discovery.ucl.ac.uk/id/document/1818709> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10203576/1/Advances%20in%20colon-targeted%20drug%20technologies.pdf> . <https://discovery.ucl.ac.uk/id/eprint/10203576/1/Advances%20in%20colon-targeted%20drug%20technologies.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "Advances in colon-targeted drug technologies.pdf"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10203576> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1818710> . <https://discovery.ucl.ac.uk/id/document/1818710> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1818710> <http://www.w3.org/2000/01/rdf-schema#label> "Advances in colon-targeted drug technologies 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<https://discovery.ucl.ac.uk/id/eprint/10203576> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1818711> . <https://discovery.ucl.ac.uk/id/document/1818711> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> . <https://discovery.ucl.ac.uk/id/document/1818711> <http://www.w3.org/2000/01/rdf-schema#label> "Advances in colon-targeted drug technologies (Other)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/document/1818711> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/document/1818711> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/document/1818711> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1818709> . <https://discovery.ucl.ac.uk/id/document/1818711> 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