eprintid: 10203574
rev_number: 9
eprint_status: archive
userid: 699
dir: disk0/10/20/35/74
datestamp: 2025-01-20 11:11:37
lastmod: 2025-01-20 11:11:37
status_changed: 2025-01-20 11:11:37
type: article
metadata_visibility: show
sword_depositor: 699
creators_name: García-Tejera, Rodrigo
creators_name: Tian, Jing-Yi
creators_name: Amoyel, Marc
creators_name: Grima, Ramon
creators_name: Schumacher, Linus J
title: Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: F96
keywords: Cell heterogeneity, Competition for niche access, Spermatogenesis, Stem cell licensing, Stem cells, Stochastic modelling
abstract: To maintain and regenerate adult tissues after injury, division and differentiation of tissue-resident stem cells must be precisely regulated. It remains elusive which regulatory strategies prevent exhaustion or overgrowth of the stem cell pool, whether there is coordination between multiple mechanisms, and how to detect them from snapshots. In Drosophila testes, somatic stem cells transition to a state that licenses them to differentiate, but remain capable of returning to the niche and resuming cell division. Here, we build stochastic mathematical models for the somatic stem cell population to investigate how licensing contributes to homeostasis. We find that licensing, in combination with differentiation occurring in pairs, is sufficient to maintain homeostasis and prevent stem cell extinction from stochastic fluctuations. Experimental data have shown that stem cells are competing for niche access, and our mathematical models demonstrate that this contributes to the reduction in the variability of stem cell numbers but does not prevent extinction. Hence, a combination of both regulation strategies, licensing with pairwise differentiation and competition for niche access, may be needed to reduce variability and prevent extinction simultaneously.
date: 2025-01
date_type: published
publisher: The Company of Biologists
official_url: https://doi.org/10.1242/dev.202796
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 2346341
doi: 10.1242/dev.202796
medium: Print-Electronic
pii: 364839
lyricists_name: Amoyel, Marc
lyricists_id: MAMOY58
actors_name: Amoyel, Marc
actors_id: MAMOY58
actors_role: owner
funding_acknowledgements: [University of Edinburgh]; [University College London]; MR/W029219/1 [Medical Research Council]; RPG-2018-423 [Leverhulme Trust]; [College of Medicine and Veterinary Medicine, University of Edinburgh]
full_text_status: public
publication: Development
volume: 152
number: 1
article_number: dev202796
event_location: England
issn: 0950-1991
citation:        García-Tejera, Rodrigo;    Tian, Jing-Yi;    Amoyel, Marc;    Grima, Ramon;    Schumacher, Linus J;      (2025)    Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance.                   Development , 152  (1)    , Article dev202796.  10.1242/dev.202796 <https://doi.org/10.1242/dev.202796>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10203574/7/Amoyel_dev202796.pdf